TY - JOUR
T1 - Natural alkaloid and polyphenol compounds targeting lipid metabolism
T2 - Treatment implications in metabolic diseases
AU - Cheng, Can
AU - Li, Zhenzhen
AU - Zhao, Xu
AU - Liao, Chaoliang
AU - Quan, Jing
AU - Bode, Ann M.
AU - Cao, Ya
AU - Luo, Xiangjian
N1 - Funding Information:
This work was supported by grants from the National Natural Science Foundation of China ( 81874195 , 81573014 ).
Publisher Copyright:
© 2020
PY - 2020/3/5
Y1 - 2020/3/5
N2 - Once the balance between lipid anabolism and catabolism is broken, metabolic disorder will occur in the organism and finally lead to metabolic diseases, such as nonalcoholic fatty liver disease (NAFLD), obesity and cancer. No established therapeutic regimens for treating NAFLD and obesity exist yet. Many natural compounds are extracted from botany, fungi and marine organisms. Importantly, natural compounds are major sources of innovative medicine. In this review, we first elucidate the important roles of lipid metabolism in NAFLD, obesity and cancer. Next, we summarize the action mechanisms of natural compounds including alkaloid, polyphenol targeting lipid metabolism. Therefore, manipulating lipid metabolism to reduce fatty acid availability may be the starting point for improving or even curing lipid metabolism-related diseases. Alkaloid and polyphenol are promising candidates for metabolic diseases to ameliorate lipid metabolism abnormalities.
AB - Once the balance between lipid anabolism and catabolism is broken, metabolic disorder will occur in the organism and finally lead to metabolic diseases, such as nonalcoholic fatty liver disease (NAFLD), obesity and cancer. No established therapeutic regimens for treating NAFLD and obesity exist yet. Many natural compounds are extracted from botany, fungi and marine organisms. Importantly, natural compounds are major sources of innovative medicine. In this review, we first elucidate the important roles of lipid metabolism in NAFLD, obesity and cancer. Next, we summarize the action mechanisms of natural compounds including alkaloid, polyphenol targeting lipid metabolism. Therefore, manipulating lipid metabolism to reduce fatty acid availability may be the starting point for improving or even curing lipid metabolism-related diseases. Alkaloid and polyphenol are promising candidates for metabolic diseases to ameliorate lipid metabolism abnormalities.
KW - Cancer
KW - Lipid metabolism
KW - Natural compound
KW - Nonalcoholic fatty liver disease
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85077737467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077737467&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2020.172922
DO - 10.1016/j.ejphar.2020.172922
M3 - Review article
C2 - 31935398
AN - SCOPUS:85077737467
SN - 0014-2999
VL - 870
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
M1 - 172922
ER -
