Natural Killer Cell-Based Immunotherapy

Jennifer A. Foltz, Jeffrey S. Miller, Dean A. Lee

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

NK cells are critical innate effector cells that serve as first responders to many viral diseases and in surveillance of early malignant transformation. Improved understanding of their biology, recognition of their importance in cancer treatment (particularly in the setting of bone marrow transplantation), and development of approaches for augmenting function and generating cells for adoptive immunotherapy have enabled a new era of clinical trials aimed at improving number and function of these cells for clinical benefit.

Original languageEnglish (US)
Title of host publicationImmunotherapy in Translational Cancer Research
PublisherWiley-Blackwell
Pages215-227
Number of pages13
ISBN (Electronic)9781118684535
ISBN (Print)9781118123225
DOIs
StatePublished - Apr 13 2018

Keywords

  • Adoptive immunotherapy
  • Antibody-dependent cellular cytotoxicity
  • Hematopoietic stem cell transplantation
  • IL-15
  • IL-2
  • KIR-mismatch
  • Natural killer cells

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