Network reconstitution for quantitative subnetwork interaction analysis

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

A fundamental task in systems biology is to quantify the contributions of the systems’ parts and their interactions. Here I describe a powerful concept and tool for this purpose: Network reconstitution. Genotypes of an organism that represent all possible combinations of the subnetworks in question will be quantitatively phenotyped. The quantitative phenotype data is analyzed using an R script to obtain estimates for single subnetwork contributions and their interactions.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages223-231
Number of pages9
DOIs
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1578
ISSN (Print)1064-3745

Bibliographical note

Funding Information:
I thank Rachel Hillmer for critical reading of the manuscript. This work was supported by grants from National Science Foundation, MCB-0918908, IOS-1121425, and MCB-1518058.

Publisher Copyright:
© Springer Science+Business Media LLC 2017.

Keywords

  • Combinatorial genotypes
  • Network reconstitution
  • Quantitative phenotype
  • Signaling allocation
  • Subnetwork interactions

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