Neurobiology of estrogen status in deep craniofacial pain

David A. Bereiter; Keiichiro Okamoto

doi:10.1016/B978-0-12-385198-7.00010-2

Neurobiology of estrogen status in deep craniofacial pain

David A. Bereiter, Keiichiro Okamoto

Basic Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

32 Scopus citations

Abstract

Pain in the temporomandibular joint (TMJ) region often occurs with no overt signs of injury or inflammation. Although the etiology of TMJ-related pain may involve multiple factors, one likely risk factor is female gender or estrogen status. Evidence is reviewed from human and animal studies, supporting the proposition that estrogen status acts peripherally or centrally to influence TMJ nociceptive processing. A new model termed the "TMJ pain matrix" is proposed as critical for the initial integration of TMJ-related sensory signals in the lower brainstem that is both modified by estrogen status, and closely linked to endogenous pain and autonomic control pathways.

Original language	English (US)
Title of host publication	International Review of Neurobiology
Publisher	Academic Press Inc.
Pages	251-284
Number of pages	34
DOIs	https://doi.org/10.1016/B978-0-12-385198-7.00010-2
State	Published - 2011

Publication series

Name	International Review of Neurobiology
Volume	97
ISSN (Print)	0074-7742
ISSN (Electronic)	0074-7742

Bibliographical note

Funding Information:
The authors were supported by a grant from the National Institutes of Health (DE12758) and the Office of Research on Womens Health. The authors thank Dr. Z. Chang for assistance in preparation of the manuscript.

Keywords

Craniofacial
Estrogen
Neurobiology
Pain control
Peripheral
Temporomandibular

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title = "Neurobiology of estrogen status in deep craniofacial pain",

abstract = "Pain in the temporomandibular joint (TMJ) region often occurs with no overt signs of injury or inflammation. Although the etiology of TMJ-related pain may involve multiple factors, one likely risk factor is female gender or estrogen status. Evidence is reviewed from human and animal studies, supporting the proposition that estrogen status acts peripherally or centrally to influence TMJ nociceptive processing. A new model termed the {"}TMJ pain matrix{"} is proposed as critical for the initial integration of TMJ-related sensory signals in the lower brainstem that is both modified by estrogen status, and closely linked to endogenous pain and autonomic control pathways.",

keywords = "Craniofacial, Estrogen, Neurobiology, Pain control, Peripheral, Temporomandibular",

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AU - Okamoto, Keiichiro

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N2 - Pain in the temporomandibular joint (TMJ) region often occurs with no overt signs of injury or inflammation. Although the etiology of TMJ-related pain may involve multiple factors, one likely risk factor is female gender or estrogen status. Evidence is reviewed from human and animal studies, supporting the proposition that estrogen status acts peripherally or centrally to influence TMJ nociceptive processing. A new model termed the "TMJ pain matrix" is proposed as critical for the initial integration of TMJ-related sensory signals in the lower brainstem that is both modified by estrogen status, and closely linked to endogenous pain and autonomic control pathways.

AB - Pain in the temporomandibular joint (TMJ) region often occurs with no overt signs of injury or inflammation. Although the etiology of TMJ-related pain may involve multiple factors, one likely risk factor is female gender or estrogen status. Evidence is reviewed from human and animal studies, supporting the proposition that estrogen status acts peripherally or centrally to influence TMJ nociceptive processing. A new model termed the "TMJ pain matrix" is proposed as critical for the initial integration of TMJ-related sensory signals in the lower brainstem that is both modified by estrogen status, and closely linked to endogenous pain and autonomic control pathways.

KW - Craniofacial

KW - Estrogen

KW - Neurobiology

KW - Pain control

KW - Peripheral

KW - Temporomandibular

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BT - International Review of Neurobiology

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ER -

Neurobiology of estrogen status in deep craniofacial pain

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