Neurochemical responses to chromatic and achromatic stimuli in the human visual cortex

Petr Bednařík, Ivan Tkáč, Federico Giove, Lynn E. Eberly, Dinesh K. Deelchand, Felipe R. Barreto, Silvia Mangia

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

In the present study, we aimed at determining the metabolic responses of the human visual cortex during the presentation of chromatic and achromatic stimuli, known to preferentially activate two separate clusters of neuronal populations (called “blobs” and “interblobs”) with distinct sensitivity to color or luminance features. Since blobs and interblobs have different cytochrome-oxidase (COX) content and micro-vascularization level (i.e., different capacities for glucose oxidation), different functional metabolic responses during chromatic vs. achromatic stimuli may be expected. The stimuli were optimized to evoke a similar load of neuronal activation as measured by the bold oxygenation level dependent (BOLD) contrast. Metabolic responses were assessed using functional 1H MRS at 7 T in 12 subjects. During both chromatic and achromatic stimuli, we observed the typical increases in glutamate and lactate concentration, and decreases in aspartate and glucose concentration, that are indicative of increased glucose oxidation. However, within the detection sensitivity limits, we did not observe any difference between metabolic responses elicited by chromatic and achromatic stimuli. We conclude that the higher energy demands of activated blobs and interblobs are supported by similar increases in oxidative metabolism despite the different capacities of these neuronal populations.

Original languageEnglish (US)
Pages (from-to)347-359
Number of pages13
JournalJournal of Cerebral Blood Flow and Metabolism
Volume38
Issue number2
Early online date2017
DOIs
StatePublished - Feb 1 2018

Bibliographical note

Publisher Copyright:
© 2017, © The Author(s) 2017.

Keywords

  • energy metabolism
  • functional MRI
  • glutamate
  • lactate
  • MR spectroscopy

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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