Neurocognitive late effects of chemotherapy in children: The past 10 years of research on brain structure and function

Fiona S Anderson, Alicia S Kunin-Batson

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations

Abstract

Advances in the treatment of childhood cancers have greatly improved survivorship. Success has not come without cost, however, as survivors are at risk for late effects of treatment, including neurocognitive late effects (e.g., difficulties with thinking and reasoning). In the advent of chemotherapy-only protocols, researchers are examining neurocognitive sequelae of these agents to understand the specific role of chemotherapy in neurocognitive changes and the mechanism through which these occur. In this review, we examine the state of the literature on neurocognitive late effects after chemotherapy and their proposed neural mechanisms.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalPediatric Blood and Cancer
Volume52
Issue number2
DOIs
StatePublished - Feb 1 2009

Keywords

  • Chemotherapy
  • Late effects
  • MRI
  • Neurocognitive
  • Neuroradiology
  • Neurotoxicity

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