TY - JOUR
T1 - Neuroendocrine control of Drosophila larval light preference
AU - Yamanaka, Naoki
AU - Romero, Nuria M.
AU - Martin, Francisco A.
AU - Rewitz, Kim F.
AU - Sun, Mu
AU - O'Connor, Michael B.
AU - Léopold, Pierre
PY - 2013/9/6
Y1 - 2013/9/6
N2 - Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors - the Bolwig's organ and the peripheral class IV dendritic arborization neurons - to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.
AB - Animal development is coupled with innate behaviors that maximize chances of survival. Here, we show that the prothoracicotropic hormone (PTTH), a neuropeptide that controls the developmental transition from juvenile stage to sexual maturation, also regulates light avoidance in Drosophila melanogaster larvae. PTTH, through its receptor Torso, acts on two light sensors - the Bolwig's organ and the peripheral class IV dendritic arborization neurons - to regulate light avoidance. We found that PTTH concomitantly promotes steroidogenesis and light avoidance at the end of larval stage, driving animals toward a darker environment to initiate the immobile maturation phase. Thus, PTTH controls the decisions of when and where animals undergo metamorphosis, optimizing conditions for adult development.
UR - http://www.scopus.com/inward/record.url?scp=84883486541&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84883486541&partnerID=8YFLogxK
U2 - 10.1126/science.1241210
DO - 10.1126/science.1241210
M3 - Article
C2 - 24009394
AN - SCOPUS:84883486541
SN - 0036-8075
VL - 341
SP - 1113
EP - 1116
JO - Science
JF - Science
IS - 6150
ER -