Abstract
The neuromodulatory effect of natriuretic peptides is probably the best example of a whole organ response mediated by natriuretic peptide C receptors (NPR-Cs). Both NPR-C specific agonists and ablation experiments utilizing NPR-C specific antibodies or antisense oligonucleotides demonstrated the essential signaling role of the NPR-C in these neuromodulatory responses. Our most recent studies utilize peptides representing the NPR-C intracellular region to elucidate the specific signaling region of the NPR-C. These studies have identified an inhibitory influence of NPR-C on adrenergic neurotransmission by a calcium-dependent process.
Original language | English (US) |
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Pages (from-to) | 1060-1067 |
Number of pages | 8 |
Journal | Peptides |
Volume | 26 |
Issue number | 6 SPEC. ISS. |
DOIs | |
State | Published - Jun 2005 |
Keywords
- Adrenergic neurotransmission
- Calcium
- Natriuretic peptide receptor C