Neuropeptides and thermoregulation: The interactions of bombesin, neurotensin, TRH, somatostatin, naloxone and prostaglandins

John E. Morley; Allen S. Levine; Martin M. Oken; Martha Grace; Julie Kneip

doi:10.1016/0196-9781(82)90132-2

Neuropeptides and thermoregulation: The interactions of bombesin, neurotensin, TRH, somatostatin, naloxone and prostaglandins

John E. Morley, Allen S. Levine, Martin M. Oken, Martha Grace, Julie Kneip

Medicine - Administration

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Abstract

In this study we have examined the interactions of bombesin (1 μg ICV), neurotensin (1 μg ICV), TRH (10 μg ICV), somatostatin (10 μg ICV), PGE₂ (10 μg ICV) and naloxone (10 mg/kg SC) on thermoregulation in the rat at room temperature (20±1°C). Given alone, bombesin, neurotensin, somatostatin and naloxone all produced hypothermia (bombesin > neurotensin > somatostatin {reversed tilde equals} naloxone). PGE₂ was hyperthermic, and TRH had no effect. Bombesin and PGE₂ neutralized one another's effects. Neurotensin had no effect on PGE₂-induced hyperthermia. Naloxone enhanced the hypothermic effect of bombesin and somatostatin enhanced the rate of onset of hypothermia after bombesin. TRH had no effect on TRH antagonized the hypothermia due to naloxone and somatostatin.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Peptides
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/0196-9781(82)90132-2
State	Published - 1982

Keywords

Bombesin
Hypothalamus
Naloxone
Neurotensin
Opiates
Prostaglandins
Somatostatin
TRH
Temperature

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title = "Neuropeptides and thermoregulation: The interactions of bombesin, neurotensin, TRH, somatostatin, naloxone and prostaglandins",

abstract = "In this study we have examined the interactions of bombesin (1 μg ICV), neurotensin (1 μg ICV), TRH (10 μg ICV), somatostatin (10 μg ICV), PGE2 (10 μg ICV) and naloxone (10 mg/kg SC) on thermoregulation in the rat at room temperature (20±1°C). Given alone, bombesin, neurotensin, somatostatin and naloxone all produced hypothermia (bombesin > neurotensin > somatostatin {reversed tilde equals} naloxone). PGE2 was hyperthermic, and TRH had no effect. Bombesin and PGE2 neutralized one another's effects. Neurotensin had no effect on PGE2-induced hyperthermia. Naloxone enhanced the hypothermic effect of bombesin and somatostatin enhanced the rate of onset of hypothermia after bombesin. TRH had no effect on TRH antagonized the hypothermia due to naloxone and somatostatin.",

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AU - Kneip, Julie

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Neuropeptides and thermoregulation: The interactions of bombesin, neurotensin, TRH, somatostatin, naloxone and prostaglandins

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