Abstract
A review of the literature finds a reported incidence of CNS complications from cancer chemotherapy ranging from 5% to 86% for different classes of drugs. Patients receiving cancer chemotherapy are rarely given a systematic psychiatric evaluation, however. Psychiatric sequelae are rarely noted in the absence of neurologic disturbances. Organic mental disorders and affective disturbances are most often noted; acute psychotic reactions are rarely seen. As detailed in this review, most changes appear reversible with the exception of a significant incidence of chronic CNS effects following high-dose intravenous or intrathecal methotrexate therapy.
Original language | English (US) |
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Pages (from-to) | 141-143 |
Number of pages | 3 |
Journal | Psychosomatics |
Volume | 21 |
Issue number | 2 |
DOIs | |
State | Published - Jan 1 1980 |