TY - JOUR
T1 - Neutrophil-induced Erythrocyte Injury
T2 - A Potential Cause of Erythrocyte Destruction in the Anemia Associated with Inflammatory Disease
AU - Weiss, D. J.
AU - Klausner, Jeffrey S
PY - 1988/11
Y1 - 1988/11
N2 - Activated neutrophils at effector/target ratios of 1:20 to 1:2,000 induced depletion of red blood cell (RBC)-reduced glutathione, increased membrane-bound hemoglobin and methemoglobin, and promoted immunoglobulin binding to the cell membrane. Superoxide dismutase/catalase ameliorated the decrease in reduced glutathione and the increase in methemoglobin and immunoglobulin binding. This is interpreted as evidence that activated neutrophils can alter the antigenic nature of the RBC membrane through generation of toxic oxygen radicals.
AB - Activated neutrophils at effector/target ratios of 1:20 to 1:2,000 induced depletion of red blood cell (RBC)-reduced glutathione, increased membrane-bound hemoglobin and methemoglobin, and promoted immunoglobulin binding to the cell membrane. Superoxide dismutase/catalase ameliorated the decrease in reduced glutathione and the increase in methemoglobin and immunoglobulin binding. This is interpreted as evidence that activated neutrophils can alter the antigenic nature of the RBC membrane through generation of toxic oxygen radicals.
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U2 - 10.1177/030098588802500608
DO - 10.1177/030098588802500608
M3 - Article
C2 - 2850649
AN - SCOPUS:0024117333
SN - 0300-9858
VL - 25
SP - 450
EP - 455
JO - Veterinary pathology
JF - Veterinary pathology
IS - 6
ER -