New bioactive bromotyrosine-derived alkaloid from a marine sponge Aplysinella sp.

Frank Joy Ankudey, Paul Kiprof, Emily R. Stromquist, Chee Chang Leng

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

A new bromotyrosine-derived alkaloid, (+)-aplysinillin (1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge Aplysinella sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1-8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in Streptomyces 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.

Original languageEnglish (US)
Pages (from-to)555-559
Number of pages5
JournalPlanta Medica
Volume74
Issue number5
DOIs
StatePublished - Apr 1 2008

Keywords

  • Bromotyrosine alkaloids
  • Hyphae formation inhibition
  • Marine sponge, Aplysinella sp.
  • Protein phosphorylation inhibitors

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