New cylindrical peptide assemblies defined by extended parallel β-sheets

Ashok D. Pehere; Christopher J. Sumby; Andrew D. Abell

doi:10.1039/c2ob26637g

New cylindrical peptide assemblies defined by extended parallel β-sheets

Ashok D. Pehere, Christopher J. Sumby, Andrew D. Abell

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A new approach to non-covalent peptide-based nanotubular or rod-like structures is presented, whereby the monomeric units are preorganised into a β-strand geometry that templates the formation of an extended and unusual parallel β-sheet rod-like structure. The conformational constraint is introduced by Huisgen cycloaddition to give a triazole-based macrocycle, with the resulting self-assembled structures stabilized by a well-defined series of intermolecular hydrogen bonds.

Original language	English (US)
Pages (from-to)	425-429
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	11
Issue number	3
DOIs	https://doi.org/10.1039/c2ob26637g
State	Published - Jan 21 2013

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New cylindrical peptide assemblies defined by extended parallel β-sheets

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