New cytotoxic cyclic peroxide acids from Plakortis sp. marine sponge

Thomas R. Hoye, Walied M. Alarif, Salim S. Basaif, Mohamed Abo-Elkarm, Mark T. Hamann, Amir E. Wahba, Seif Eldin N Ayyad

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Bioassay-guided fractionation of the extract of Jamaican marine sponge Plakortis sp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (1a, 2a, 3a, 4, 5), known plakortides (6,7), known bicyclic lactone (8) and new cyclic peroxide acids (1b, 2b, 3b). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines.

Original languageEnglish (US)
Pages (from-to)164-175
Number of pages12
JournalArkivoc
Volume2015
Issue number5
DOIs
StatePublished - Apr 5 2015

Bibliographical note

Publisher Copyright:
©ARKAT-USA, Inc.

Keywords

  • Cyclic peroxides
  • Cytotoxicity
  • Plakortis sponge
  • Polyketides

Fingerprint

Dive into the research topics of 'New cytotoxic cyclic peroxide acids from Plakortis sp. marine sponge'. Together they form a unique fingerprint.

Cite this