New cytotoxic cyclic peroxide acids from Plakortis sp. marine sponge

Thomas R. Hoye, Walied M. Alarif, Salim S. Basaif, Mohamed Abo-Elkarm, Mark T. Hamann, Amir E. Wahba, Seif Eldin N Ayyad

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Bioassay-guided fractionation of the extract of Jamaican marine sponge Plakortis sp. followed by preparative TLC and HPLC yielded several known methyl ester cyclic peroxides (1a, 2a, 3a, 4, 5), known plakortides (6,7), known bicyclic lactone (8) and new cyclic peroxide acids (1b, 2b, 3b). The chemical structures were elucidated by extensive interpretation of their spectroscopic data. These natural products showed remarkable in vitro cytotoxicity against several cancer cell lines.

Original languageEnglish (US)
Pages (from-to)164-175
Number of pages12
Issue number5
StatePublished - Apr 5 2015

Bibliographical note

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  • Cyclic peroxides
  • Cytotoxicity
  • Plakortis sponge
  • Polyketides


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