Abstract
The role of genotypic analysis in disease diagnostics and drug response assessment is continually expanding. New genomic discoveries combined with new, novel technologies may provide a greater range of testing capabilities in the near future. We describe the application of nanotechnology, in which DNA microarrays have been placed in a microchannel environment that can be read and analyzed in an optical (CD/DVD) disc drive system. The potential exists to combine molecular and immunological applications together into a rapid, low-cost, high-capacity screening platform. The relevance of this technology is discussed in respect to infectious agent detection, pharmacogenomics, neurogenomics and genetic variations associated with neurologic diseases.
Original language | English (US) |
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Pages (from-to) | 193-206 |
Number of pages | 14 |
Journal | Psychiatric Genetics |
Volume | 12 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1 2002 |
Keywords
- CD/DVD discs
- Gene variants
- Genotyping
- MEMS
- Microarrays
- Nanotechnology
- Neurogenomics
- Neurologic disorders
- Optical discs
- Pathogen detection
- Pharmacogenomics