New Materials for Biotechnology: Chromatographic Stationary Phases Based on Zirconia

Jacek Nawrocki, Christopher J. Dunlap, Peter W. Carr, John A. Blackwell

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations

Abstract

This review explores the usefulness of zirconia‐based materials in separations in biotechnology. The physical and chemical properties of zirconia are discussed briefly to familiarize the reader with the advantages of zirconia. The use of native zirconia is then examined, with a study of the Lewis acid/base chemistry that defines chromatography with zirconia. Modification of the zirconia surface with small molecules is then discussed. Finally, polymer‐coated zirconia materials are examined. Examples of separations using these various materials are shown. The advantages and disadvantages of each of these materials are presented.

Original languageEnglish (US)
Pages (from-to)561-573
Number of pages13
JournalBiotechnology Progress
Volume10
Issue number6
DOIs
StatePublished - Jan 1 1994

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