A new strategy to prepare pyrophosphate analogues through selective and quantitative cleavage of N-(O-alkylsulfamoyl)trialkylphospha-λ 5-azene esters (R-O-SO2-NP(OR′)3) has been developed. Using pure bromotrimethylsilane, N-(O-alkyl-sulfamoyl) tristrimethylsilylphospha-λ5-azenes (R-O-SO 2-NP(OSiMe3)3) have been easily obtained as intermediates. N-(O-Alkyl-sulfamoyl)phosphoramidic acids (R-O-SO 2-NH-P(O)(OH)2) have been formed quantitatively by hydrolysis of the silylated intermediates.
Bibliographical noteFunding Information:
Financial support of this work by La Ligue contre le Cancer (Comité de l'Aude et du Gard) (L. B PhD fellowship) is gratefully acknowledged.
- Pyrophosphate analogues