Surface plasmon resonance (SPR)-based biosensing is one of the most advanced label free, real time detection technologies. Numerous research groups with divergent scientific backgrounds have investigated the application of SPR biosensors and studied the fundamental aspects of surface plasmon polaritons that led to new, related instrumentation. As a result, this field continues to be at the forefront of evolving sensing technology. This review emphasizes the new developments in the field of SPR-related instrumentation including optical platforms, chips design, nanoscale approach and new materials. The current tendencies in SPR-based biosensing are identified and the future direction of SPR biosensor technology is broadly discussed.
Bibliographical noteFunding Information:
The authors gratefully acknowledge the financial support of the US National Science Foundation ( CHE-0719224 ) and the National Institute of Health ( 1R21EB-009551 ).
Copyright 2011 Elsevier B.V., All rights reserved.
- Biochip design
- Label-free detection
- Optical sensor
- SPR imaging
- Surface plasmon resonance