NF-κB inducing kinase: A key regulator in the immune system and in cancer

Yee Mon Thu, A. Richmond

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

NF-κB inducing kinase (NIK) is a kinase that activates the canonical and non-canonical NF-κB pathways to control transcriptional expression of certain proteins such as cytokines, chemokines and NF-κB signaling molecules. Many advances have been made in understanding the molecular mechanisms by which the stability of NIK is regulated to affect downstream signaling. Genetic mouse models suggest that NIK plays an essential role in the regulation of the immune system as well as in the bone microenvironment. Increasing evidence links NIK to the tumorigenesis of hematological cancers, such as multiple myeloma, and solid tumors, such as pancreatic carcinoma and melanoma. Understanding the mechanism by which NIK is de-regulated will potentially provide therapeutic options for certain diseases such as autoimmunity and cancer.

Original languageEnglish (US)
Pages (from-to)213-226
Number of pages14
JournalCytokine and Growth Factor Reviews
Volume21
Issue number4
DOIs
StatePublished - Aug 2010

Bibliographical note

Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.

Keywords

  • Canonical pathway
  • IKK
  • NF-κB
  • NF-κB inducing kinase (NIK)
  • Non-canonical pathway

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