TY - JOUR
T1 - NHLBI Family Heart Study
T2 - Objectives and design
AU - Higgins, Millicent
AU - Province, Michael
AU - Heiss, Gerardo
AU - Eckfeldt, John
AU - Curtis Ellison, R.
AU - Folsom, Aaron R.
AU - Rao, D. C.
AU - Sprafka, J. Michael
AU - Williams, Roger
N1 - Funding Information:
Supported by contracts NO1-HC-25104, NO1-HC-25105, NO1-HC-25106, NO1-HC-25107, NO1-HC-25108, and NO1-HC-25109 from the National Heart, Lung, and Blood Institute.
PY - 1996/6/15
Y1 - 1996/6/15
N2 - The NHLBI Family Heart Study is a multicenter, population-based study of genetic and nongenetic determinants of coronary heart disease (CHD), atherosclerosis, and cardiovascular risk factors. In phase I, 2,000 randomly selected participants and 2,000 with family histories of CHD were identified among 14,592 middle-aged participants in epidemiologic studies. Medical histories from these individuals, their parents, and their siblings were used to calculate family risk scores that compared the number of reported and validated CHD events with the number expected based on the size, sex, and age of family members. A total of 657 families with the highest risk scores and early-onset CHD and 588 randomly sampled families had clinic examinations that included electrocardiograms, carotid artery ultrasound scans, spirometry, measurements of body size, blood pressure, lipids, lipoproteins, hemostatic factors, insulin, glucose, and routine chemistries. Additional biochemical and genetic studies are being performed on selected participants. Serum, plasma, lymphocytes, red cells, and DNA are stored for future studies, including genotyping of candidate genes and anonymous markers. Contributions of genes, shared and individual environments, and behaviors to variations in risk factors, preclinical atherosclerosis, and CHD will be estimated. Linkage studies, including the quantitative trait loci approach, are planned.
AB - The NHLBI Family Heart Study is a multicenter, population-based study of genetic and nongenetic determinants of coronary heart disease (CHD), atherosclerosis, and cardiovascular risk factors. In phase I, 2,000 randomly selected participants and 2,000 with family histories of CHD were identified among 14,592 middle-aged participants in epidemiologic studies. Medical histories from these individuals, their parents, and their siblings were used to calculate family risk scores that compared the number of reported and validated CHD events with the number expected based on the size, sex, and age of family members. A total of 657 families with the highest risk scores and early-onset CHD and 588 randomly sampled families had clinic examinations that included electrocardiograms, carotid artery ultrasound scans, spirometry, measurements of body size, blood pressure, lipids, lipoproteins, hemostatic factors, insulin, glucose, and routine chemistries. Additional biochemical and genetic studies are being performed on selected participants. Serum, plasma, lymphocytes, red cells, and DNA are stored for future studies, including genotyping of candidate genes and anonymous markers. Contributions of genes, shared and individual environments, and behaviors to variations in risk factors, preclinical atherosclerosis, and CHD will be estimated. Linkage studies, including the quantitative trait loci approach, are planned.
KW - coronary heart disease
KW - genetics
KW - hypertension
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=0029941114&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029941114&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.aje.a008709
DO - 10.1093/oxfordjournals.aje.a008709
M3 - Article
C2 - 8651220
AN - SCOPUS:0029941114
SN - 0002-9262
VL - 143
SP - 1219
EP - 1228
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 12
ER -
