Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells

Medicine & Life Sciences

• Nicotinic Receptors 89%
• Nicotine 80%
• Non-Small Cell Lung Carcinoma 72%
• Signal Transduction 63%
• Muscles 49%
• Mitogen-Activated Protein Kinases 29%
• Hexamethonium 19%
• Gefitinib 18%
• Lung 15%
• Cell Line 13%
• Messenger RNA 12%
• Proteins 10%
• Tobacco Use Cessation Devices 10%
• Bungarotoxins 10%
• L-Type Calcium Channels 9%
• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 8%
• Protein Subunits 8%
• Cholinergic Antagonists 8%
• Cell Extracts 7%
• Phosphatidylinositol 3-Kinases 7%
• Neoplasms 7%
• Tobacco Products 6%
• Acetylcholine 6%
• Protein-Tyrosine Kinases 6%
• Cell Count 5%
• Epithelial Cells 5%
• Immunohistochemistry 5%
• Phosphorylation 5%
• Calcium 5%
• Survival 4%
• Therapeutics 1%

Chemical Compounds

• Nicotine 100%
• Acetylcholine 87%
• Protein 27%
• Hexamethonium 23%
• Gefitinib 23%
• Antagonist 13%
• LY294002 13%
• Tyrosine Kinase Inhibitor 10%
• Agent Interacting With Transmitter, Hormone or Drug Receptor 8%
• Calcium(0) 5%