Nitric oxide modulation of the spontaneous firing of rat medial vestibular nuclear neurons

Hoo Won Kim, Jong Seong Park, Han Seong Jeong, Myung Joo Jang, Byeong Chae Kim, Myeong Kyu Kim, Ki Hyun Cho, Tae Sun Kim, Sung Wook Park

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Modulation of the spontaneous activity of rat medial vestibular nuclear neurons by nitric oxide was investigated using the whole-cell patch-clamp technique. The spike frequency was increased by sodium nitroprusside (SNP), a nitric oxide liberating agent, and it was also increased by another nitric oxide liberating agent, sodium-nitroso-N-acetylpenicillamine. L-Arginine, the substrate of nitric oxide synthase, increased the firing of the neurons. The increased SNP-induced firing was inhibited by 1H-[1,2,4]oxadiazolo[4,3-a] quinozalin-1-one (ODQ), a specific inhibitor of guanylate cyclase. These results suggest that nitric oxide increases the neuronal excitability of the neurons by a cGMP-dependent mechanism.

Original languageEnglish (US)
Pages (from-to)224-228
Number of pages5
JournalJournal of Pharmacological Sciences
Volume96
Issue number2
DOIs
StatePublished - Oct 2004

Keywords

  • Action potential
  • Medial vestibular nucleus
  • Nitric oxide

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