NMDA R1 mRNA distribution in motor and thalamic-projecting sensory neurons in the rat spinal cord and brain stem

Laura Kus; Dale Saxon; Alvin J. Beitz

doi:10.1016/0304-3940(95)11878-Z

NMDA R1 mRNA distribution in motor and thalamic-projecting sensory neurons in the rat spinal cord and brain stem

Laura Kus, Dale Saxon, Alvin J. Beitz

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Abstract

The N-methyl-D-aspartate (NMDA) receptor is important in both sensory and motor neurotransmission. In this study we examine NMDA R1 mRNA hybridization signal over individual sensory and motor neurons in the spinal cord and brain stem. A significantly greater quantity of NMDA RI mRNA was present in motor neurons of the lumbar spinal cord and hypoglossal nucleus compared to thalamic projecting sensory neurons in the spinal cord dorsal horn, the spinal trigeminal nucleus pars caudalis and the cuneate and gracile nuclei. No significant difference in the quantity of NMDA R1 mRNA was observed between sensory neurons known to relay predominantly nociceptive information (trigeminothalamic and spinothalamic tract neurons) and those that relay predominantly touch and proprioceptive information (dorsal column neurons).

Original language	English (US)
Pages (from-to)	201-204
Number of pages	4
Journal	Neuroscience Letters
Volume	196
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(95)11878-Z
State	Published - Aug 25 1995

Keywords

Dorsal column nuclei
Hypoglossal
In situ hybridization
Motor neurons
NMDA
NMDA R1
Spinal cord
Spinothalamic

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title = "NMDA R1 mRNA distribution in motor and thalamic-projecting sensory neurons in the rat spinal cord and brain stem",

abstract = "The N-methyl-D-aspartate (NMDA) receptor is important in both sensory and motor neurotransmission. In this study we examine NMDA R1 mRNA hybridization signal over individual sensory and motor neurons in the spinal cord and brain stem. A significantly greater quantity of NMDA RI mRNA was present in motor neurons of the lumbar spinal cord and hypoglossal nucleus compared to thalamic projecting sensory neurons in the spinal cord dorsal horn, the spinal trigeminal nucleus pars caudalis and the cuneate and gracile nuclei. No significant difference in the quantity of NMDA R1 mRNA was observed between sensory neurons known to relay predominantly nociceptive information (trigeminothalamic and spinothalamic tract neurons) and those that relay predominantly touch and proprioceptive information (dorsal column neurons).",

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AU - Saxon, Dale

AU - Beitz, Alvin J.

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N2 - The N-methyl-D-aspartate (NMDA) receptor is important in both sensory and motor neurotransmission. In this study we examine NMDA R1 mRNA hybridization signal over individual sensory and motor neurons in the spinal cord and brain stem. A significantly greater quantity of NMDA RI mRNA was present in motor neurons of the lumbar spinal cord and hypoglossal nucleus compared to thalamic projecting sensory neurons in the spinal cord dorsal horn, the spinal trigeminal nucleus pars caudalis and the cuneate and gracile nuclei. No significant difference in the quantity of NMDA R1 mRNA was observed between sensory neurons known to relay predominantly nociceptive information (trigeminothalamic and spinothalamic tract neurons) and those that relay predominantly touch and proprioceptive information (dorsal column neurons).

AB - The N-methyl-D-aspartate (NMDA) receptor is important in both sensory and motor neurotransmission. In this study we examine NMDA R1 mRNA hybridization signal over individual sensory and motor neurons in the spinal cord and brain stem. A significantly greater quantity of NMDA RI mRNA was present in motor neurons of the lumbar spinal cord and hypoglossal nucleus compared to thalamic projecting sensory neurons in the spinal cord dorsal horn, the spinal trigeminal nucleus pars caudalis and the cuneate and gracile nuclei. No significant difference in the quantity of NMDA R1 mRNA was observed between sensory neurons known to relay predominantly nociceptive information (trigeminothalamic and spinothalamic tract neurons) and those that relay predominantly touch and proprioceptive information (dorsal column neurons).

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KW - Motor neurons

KW - NMDA

KW - NMDA R1

KW - Spinal cord

KW - Spinothalamic

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NMDA R1 mRNA distribution in motor and thalamic-projecting sensory neurons in the rat spinal cord and brain stem

Abstract

Keywords

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