No association of 9p21 with arterial elasticity and retinal microvascular findings

Aaron R. Folsom; James S. Pankow; Xiaohui Li; Daniel A. Duprez; David R. Jacobs; Ronald Klein; Barbara Klein; Weihong Tang; Tien Yin Wong; Mary Frances Cotch; Kent D. Taylor; Stephen S. Rich; Jennifer L. Hall; Wendy S. Post; Jerome I. Rotter

doi:10.1016/j.atherosclerosis.2013.07.049

No association of 9p21 with arterial elasticity and retinal microvascular findings

Aaron R. Folsom, James S. Pankow, Xiaohui Li, Daniel A. Duprez, David R. Jacobs, Ronald Klein, Barbara Klein, Weihong Tang, Tien Yin Wong, Mary Frances Cotch, Kent D. Taylor, Stephen S. Rich, Jennifer L. Hall, Wendy S. Post, Jerome I. Rotter

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective: How 9p21 variation affects risk of cardiovascular disease is unclear, so we assessed whether 9p21 variants are associated with arterial elasticity or retinal microvascular findings. Methods: In the prospective Multi-Ethnic Study of Atherosclerosis (MESA) we assessed 378 SNPs in the 9p21 locus. Within four ethnic groups, we used an additive genetic model to relate the 9p21 SNPs to five vascular phenotypes: small and large elasticity derived from radial diastolic pulse contour analysis; Young's elastic modulus from carotid artery ultrasound measurements; and the diameter of the central retinal arteries and veins. Results: In neither ethnic-specific nor pooled data was there any statistically significant association between any of the 9p21 SNPs and any of the five vascular phenotypes. Conclusion: Our study does not support an association of 9p21 variation with arterial elasticity or retinal microvascular abnormalities.

Original language	English (US)
Pages (from-to)	301-303
Number of pages	3
Journal	Atherosclerosis
Volume	230
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2013.07.049
State	Published - Oct 2013

Bibliographical note

Funding Information:
This research was supported by contracts N01-HC-95159 through N01-HC-95169 , N01-HC-65226 , and N02-HL-64278 from the National Heart, Lung, and Blood Institute and by grants UL1-RR-024156 and UL1-RR-025005 from the National Center for Research Resources . The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org .

Keywords

9p21 SNP
Arterial elasticity
Prospective study
Retinal microvascular abnormalities

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Folsom, A. R., Pankow, J. S., Li, X., Duprez, D. A., Jacobs, D. R., Klein, R., Klein, B., Tang, W., Wong, T. Y., Cotch, M. F., Taylor, K. D., Rich, S. S., Hall, J. L., Post, W. S., & Rotter, J. I. (2013). No association of 9p21 with arterial elasticity and retinal microvascular findings. Atherosclerosis, 230(2), 301-303. https://doi.org/10.1016/j.atherosclerosis.2013.07.049

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abstract = "Objective: How 9p21 variation affects risk of cardiovascular disease is unclear, so we assessed whether 9p21 variants are associated with arterial elasticity or retinal microvascular findings. Methods: In the prospective Multi-Ethnic Study of Atherosclerosis (MESA) we assessed 378 SNPs in the 9p21 locus. Within four ethnic groups, we used an additive genetic model to relate the 9p21 SNPs to five vascular phenotypes: small and large elasticity derived from radial diastolic pulse contour analysis; Young's elastic modulus from carotid artery ultrasound measurements; and the diameter of the central retinal arteries and veins. Results: In neither ethnic-specific nor pooled data was there any statistically significant association between any of the 9p21 SNPs and any of the five vascular phenotypes. Conclusion: Our study does not support an association of 9p21 variation with arterial elasticity or retinal microvascular abnormalities.",

keywords = "9p21 SNP, Arterial elasticity, Prospective study, Retinal microvascular abnormalities",

author = "Folsom, {Aaron R.} and Pankow, {James S.} and Xiaohui Li and Duprez, {Daniel A.} and Jacobs, {David R.} and Ronald Klein and Barbara Klein and Weihong Tang and Wong, {Tien Yin} and Cotch, {Mary Frances} and Taylor, {Kent D.} and Rich, {Stephen S.} and Hall, {Jennifer L.} and Post, {Wendy S.} and Rotter, {Jerome I.}",

note = "Funding Information: This research was supported by contracts N01-HC-95159 through N01-HC-95169 , N01-HC-65226 , and N02-HL-64278 from the National Heart, Lung, and Blood Institute and by grants UL1-RR-024156 and UL1-RR-025005 from the National Center for Research Resources . The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org . ",

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AU - Folsom, Aaron R.

AU - Pankow, James S.

AU - Li, Xiaohui

AU - Duprez, Daniel A.

AU - Jacobs, David R.

AU - Klein, Ronald

AU - Klein, Barbara

AU - Tang, Weihong

AU - Wong, Tien Yin

AU - Cotch, Mary Frances

AU - Taylor, Kent D.

AU - Rich, Stephen S.

AU - Hall, Jennifer L.

AU - Post, Wendy S.

AU - Rotter, Jerome I.

N1 - Funding Information: This research was supported by contracts N01-HC-95159 through N01-HC-95169 , N01-HC-65226 , and N02-HL-64278 from the National Heart, Lung, and Blood Institute and by grants UL1-RR-024156 and UL1-RR-025005 from the National Center for Research Resources . The authors thank the other investigators, the staff, and the participants of the MESA study for their valuable contributions. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org .

PY - 2013/10

Y1 - 2013/10

N2 - Objective: How 9p21 variation affects risk of cardiovascular disease is unclear, so we assessed whether 9p21 variants are associated with arterial elasticity or retinal microvascular findings. Methods: In the prospective Multi-Ethnic Study of Atherosclerosis (MESA) we assessed 378 SNPs in the 9p21 locus. Within four ethnic groups, we used an additive genetic model to relate the 9p21 SNPs to five vascular phenotypes: small and large elasticity derived from radial diastolic pulse contour analysis; Young's elastic modulus from carotid artery ultrasound measurements; and the diameter of the central retinal arteries and veins. Results: In neither ethnic-specific nor pooled data was there any statistically significant association between any of the 9p21 SNPs and any of the five vascular phenotypes. Conclusion: Our study does not support an association of 9p21 variation with arterial elasticity or retinal microvascular abnormalities.

AB - Objective: How 9p21 variation affects risk of cardiovascular disease is unclear, so we assessed whether 9p21 variants are associated with arterial elasticity or retinal microvascular findings. Methods: In the prospective Multi-Ethnic Study of Atherosclerosis (MESA) we assessed 378 SNPs in the 9p21 locus. Within four ethnic groups, we used an additive genetic model to relate the 9p21 SNPs to five vascular phenotypes: small and large elasticity derived from radial diastolic pulse contour analysis; Young's elastic modulus from carotid artery ultrasound measurements; and the diameter of the central retinal arteries and veins. Results: In neither ethnic-specific nor pooled data was there any statistically significant association between any of the 9p21 SNPs and any of the five vascular phenotypes. Conclusion: Our study does not support an association of 9p21 variation with arterial elasticity or retinal microvascular abnormalities.

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No association of 9p21 with arterial elasticity and retinal microvascular findings

Abstract

Bibliographical note

Keywords

UN SDGs

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