Nociception is enhanced by the intrathecal injection of 5-methoxy-N,N-dimethyltryptamine in the rat

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Abstract

The effect of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) at the spinal cord level on nociceptive reflexes was tested using the tail-flick assay in rats. 5-MeODMT was injected directly into the spinal subarachnoid space of conscious rats via a permanently indwelling intrathecal cannula. Administration of 100 μg/rat of 5-MeODMT into the thoracic region, using a 4 cm long cannula, reduced the average percent of control reaction time by 14%. The injection of the same dose of 5-MeODMT into the lumbosacral region, via an 8.6 cm long cannula, decreased the average percent of control reaction time by 25%. The ability of 5-MeODMT to mimic the facilitatory (hyperalgesic effect on nociception of similar doses of tryptamine, in contrast to the antinociceptive (analgesic) effect of serotonin, suggests an interaction of 5-MeODMT with tryptaminergic rather than serotonergic receptors in the spinal cord.

Original languageEnglish (US)
Pages (from-to)323-328
Number of pages6
JournalNeuroscience Letters
Volume33
Issue number3
DOIs
StatePublished - Dec 13 1982

Keywords

  • 5-methoxy-N,N-dimethy
  • intrathecal injection
  • nociception
  • serotonin
  • spinal cord
  • tryptamine

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