Abstract
The effect of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) at the spinal cord level on nociceptive reflexes was tested using the tail-flick assay in rats. 5-MeODMT was injected directly into the spinal subarachnoid space of conscious rats via a permanently indwelling intrathecal cannula. Administration of 100 μg/rat of 5-MeODMT into the thoracic region, using a 4 cm long cannula, reduced the average percent of control reaction time by 14%. The injection of the same dose of 5-MeODMT into the lumbosacral region, via an 8.6 cm long cannula, decreased the average percent of control reaction time by 25%. The ability of 5-MeODMT to mimic the facilitatory (hyperalgesic effect on nociception of similar doses of tryptamine, in contrast to the antinociceptive (analgesic) effect of serotonin, suggests an interaction of 5-MeODMT with tryptaminergic rather than serotonergic receptors in the spinal cord.
Original language | English (US) |
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Pages (from-to) | 323-328 |
Number of pages | 6 |
Journal | Neuroscience Letters |
Volume | 33 |
Issue number | 3 |
DOIs | |
State | Published - Dec 13 1982 |
Externally published | Yes |
Keywords
- 5-methoxy-N,N-dimethy
- intrathecal injection
- nociception
- serotonin
- spinal cord
- tryptamine