The NOESY (nuclear Overhauser enhancement spectroscopy) Jigsaw algorithm is a novel high-throughput, automated approach to protein structure characterization with nuclear magnetic resonance. Jigsaw applies algorithms and probabilistic reasoning techniques, enforcing first-principles consistency rules in order to overcome a 5-10% signal-to-noise ratio. Results for three test proteins demonstrate that the method was able to identify and align approximately 80% of α-helical and 60% of β-sheet structure.
|Original language||English (US)|
|Number of pages||12|
|State||Published - Jan 1 2000|
|Event||RECOMB 2000: 4th Annual International Conference on Computational Molecular Biology - Tokyo, Jpn|
Duration: Apr 8 2000 → Apr 11 2000
|Other||RECOMB 2000: 4th Annual International Conference on Computational Molecular Biology|
|Period||4/8/00 → 4/11/00|