Non-contact sub-nanometer measurement of transient surface displacement during action potential propagation

Taner Akkin; Digant P. Davé; H. Grady Rylander; Thomas E. Milner

doi:10.1117/12.592026

Non-contact sub-nanometer measurement of transient surface displacement during action potential propagation

Taner Akkin, Digant P. Davé, H. Grady Rylander, Thomas E. Milner

Biomedical Engineering

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

We have demonstrated non-contact, sub-nanometer optical measurement of neural surface displacement associated with action potential propagation without applying exogenous chemicals or reflection coatings. Signals recorded from crayfish leg nerve using a phase-sensitive optical low coherence reflectometer show that transient neural surface displacement due to action potential propagation is approximately 1 nm in amplitude and 1 ms in duration. Measured optical signals are coincident with electrical action potential arrival to the optical measurement site. Recent experiments indicate signals with similar amplitude and duration are observed in response to repetitive fast stimulation (200 stimuli/s).

Original language	English (US)
Article number	68
Pages (from-to)	408-411
Number of pages	4
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	5690
DOIs	https://doi.org/10.1117/12.592026
State	Published - 2005
Event	Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX - San Jose, CA, United States Duration: Jan 23 2005 → Jan 26 2005

Keywords

Action potential
Interferometer
Neural activity
Phase sensitive
Surface displacement
Swelling

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title = "Non-contact sub-nanometer measurement of transient surface displacement during action potential propagation",

abstract = "We have demonstrated non-contact, sub-nanometer optical measurement of neural surface displacement associated with action potential propagation without applying exogenous chemicals or reflection coatings. Signals recorded from crayfish leg nerve using a phase-sensitive optical low coherence reflectometer show that transient neural surface displacement due to action potential propagation is approximately 1 nm in amplitude and 1 ms in duration. Measured optical signals are coincident with electrical action potential arrival to the optical measurement site. Recent experiments indicate signals with similar amplitude and duration are observed in response to repetitive fast stimulation (200 stimuli/s).",

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AU - Davé, Digant P.

AU - Rylander, H. Grady

AU - Milner, Thomas E.

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AB - We have demonstrated non-contact, sub-nanometer optical measurement of neural surface displacement associated with action potential propagation without applying exogenous chemicals or reflection coatings. Signals recorded from crayfish leg nerve using a phase-sensitive optical low coherence reflectometer show that transient neural surface displacement due to action potential propagation is approximately 1 nm in amplitude and 1 ms in duration. Measured optical signals are coincident with electrical action potential arrival to the optical measurement site. Recent experiments indicate signals with similar amplitude and duration are observed in response to repetitive fast stimulation (200 stimuli/s).

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KW - Interferometer

KW - Neural activity

KW - Phase sensitive

KW - Surface displacement

KW - Swelling

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Non-contact sub-nanometer measurement of transient surface displacement during action potential propagation

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