Non-invasive studies of peripheral vascular compliance using a non-occluding photoplethysmographic method

E. A. López-Beltrán; P. L. Blackshear; Stanley M Finkelstein; Jay N Cohn

doi:10.1007/BF02518879

Non-invasive studies of peripheral vascular compliance using a non-occluding photoplethysmographic method

E. A. López-Beltrán, P. L. Blackshear, Stanley M Finkelstein, Jay N Cohn

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Abstract

A non-invasive technique is implemented to measure a peripheral vascular compliance index C_index, using an infrared photoplethysmographic waveform as an indicator of intravascular volume change and a continuous blood pressure monitor to measure the blood pressure during each heart-beat. The non-linear behaviour of C_index with pressure and the effect of age on C_index are studied in 62 males (15-73 years). Repeatability tests and the effect of ice-water exposure of a portion of a limb are studied in 10 and 14 subjects, respectively. For each individual, C_index measurements are taken at discrete values of local mean arterial pressure (P_mean), and a C_index against P_mean plot is obtained. There is a statistically significant difference (p<0.05) in C_index tor the lower values of P_mean (60-100 mmHg) between two age groups formed (15-52 and 58-73 years). The cold-pressor test (CPT) shows a 68% median decrease in C_index, with an inter-quartile range of 60-77%, in a matter of seconds. The results suggest that C_index may be a useful noninvasive indicator of peripheral vascular compliance in humans.

Original language	English (US)
Pages (from-to)	748-753
Number of pages	6
Journal	Medical and Biological Engineering and Computing
Volume	36
Issue number	6
DOIs	https://doi.org/10.1007/BF02518879
State	Published - 1998

Bibliographical note

Funding Information:
Acknowledgments--This work was supported by NIH (MARC Predoctoral Research Fellowship, Grant F31 GM 09586-06). We would like to thank Dr Phillip Isaacson (Vice President, NONIN MEDICAL, Inc.) for providing a pulse oximeter for this study.

Keywords

Age-effect
Non-invasive compliance
Peripheral compliance
Photoplethysmography
Pressure-dependent compliance
Repeatability

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title = "Non-invasive studies of peripheral vascular compliance using a non-occluding photoplethysmographic method",

abstract = "A non-invasive technique is implemented to measure a peripheral vascular compliance index Cindex, using an infrared photoplethysmographic waveform as an indicator of intravascular volume change and a continuous blood pressure monitor to measure the blood pressure during each heart-beat. The non-linear behaviour of Cindex with pressure and the effect of age on Cindex are studied in 62 males (15-73 years). Repeatability tests and the effect of ice-water exposure of a portion of a limb are studied in 10 and 14 subjects, respectively. For each individual, Cindex measurements are taken at discrete values of local mean arterial pressure (Pmean), and a Cindex against Pmean plot is obtained. There is a statistically significant difference (p<0.05) in Cindex tor the lower values of Pmean (60-100 mmHg) between two age groups formed (15-52 and 58-73 years). The cold-pressor test (CPT) shows a 68% median decrease in Cindex, with an inter-quartile range of 60-77%, in a matter of seconds. The results suggest that Cindex may be a useful noninvasive indicator of peripheral vascular compliance in humans.",

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note = "Funding Information: Acknowledgments--This work was supported by NIH (MARC Predoctoral Research Fellowship, Grant F31 GM 09586-06). We would like to thank Dr Phillip Isaacson (Vice President, NONIN MEDICAL, Inc.) for providing a pulse oximeter for this study.",

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AU - Finkelstein, Stanley M

AU - Cohn, Jay N

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Non-invasive studies of peripheral vascular compliance using a non-occluding photoplethysmographic method

Abstract

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Keywords

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