Nonimmune hydrops fetalis and fulminant fatal disease due to congenital cytomegalovirus infection in a premature infant

Venkatesh Sampath, Vivek Narendan, Edward F. Donovan, Jerzy Stanek, Mark R. Schleiss

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

We report a case of fatal congenital cytomegalovirus (CMV) disease in a 695gm, 29 weeks estimated gestational age premature infant. The newborn presented with hydrops fetalis, an unusual presentation of congenital CMV infection. In spite of ganciclovir therapy, the infant succumbed to his illness. Autopsy findings revealed the presence of widespread CMV disease, including pneumonitis, enteritis, and myocarditis. Congenital CMV infection should be considered in the differential diagnosis of hydrops fetalis.

Original languageEnglish (US)
Pages (from-to)608-611
Number of pages4
JournalJournal of Perinatology
Volume25
Issue number9
DOIs
StatePublished - Sep 2005

Bibliographical note

Funding Information:
Helpful discussions with Tenessa MacKenzie, University of Florida School of Medicine, are acknowledged. Grant support is acknowledged for study of congenital CMV infection (NIH HD38416-01, HD44864-01, and the March of Dimes Birth Defects Foundations FY01-22).

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