Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism

Jae G. Kim; Jangwoen Lee; Sari B. Mahon; David Mukai; Steven E. Patterson; Gerry R. Boss; Bruce J. Tromberg; Matthew Brenner

doi:10.1117/1.JBO.17.10.105005

Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism

Jae G. Kim, Jangwoen Lee, Sari B. Mahon, David Mukai, Steven E. Patterson, Gerry R. Boss, Bruce J. Tromberg, Matthew Brenner

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Noninvasive near infrared spectroscopy measurements were performed to monitor cyanide (CN) poisoning and recovery in the brain region and in foreleg muscle simultaneously, and the effects of a novel CN antidote, sulfanegen sodium, on tissue hemoglobin oxygenation changes were compared using a sub-lethal rabbit model. The results demonstrated that the brain region is more susceptible to CN poisoning and slower in endogenous CN detoxification following exposure than peripheral muscles. However, sulfanegen sodium rapidly reversed CN toxicity, with brain region effects reversing more quickly than muscle. In vivo monitoring of multiple organs may provide important clinical information regarding the extent of CN toxicity and subsequent recovery, and facilitate antidote drug development.

Original language	English (US)
Article number	105005
Journal	Journal of biomedical optics
Volume	17
Issue number	10
DOIs	https://doi.org/10.1117/1.JBO.17.10.105005
State	Published - Oct 2012

Bibliographical note

Funding Information:
This work was supported by the AF [9550-04-1-0101, 9550-08-1-0384]; the Laser Microbeam and Medical Program from the National Center for Research Resources [P41RR001192]; the National Institutes of Health [1U54NS063718, U01-NS058030]; Basic research project and APRI-research program through grants provided by GIST, Korea. The authors thank David Yoon for his help in manuscript editing and preparation.

Keywords

Brain
Cyanide antidote
Cyanide poisoning
Diffuse optical spectroscopy
Metabolism
Muscle
Sulfanegen sodium

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title = "Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism",

abstract = "Noninvasive near infrared spectroscopy measurements were performed to monitor cyanide (CN) poisoning and recovery in the brain region and in foreleg muscle simultaneously, and the effects of a novel CN antidote, sulfanegen sodium, on tissue hemoglobin oxygenation changes were compared using a sub-lethal rabbit model. The results demonstrated that the brain region is more susceptible to CN poisoning and slower in endogenous CN detoxification following exposure than peripheral muscles. However, sulfanegen sodium rapidly reversed CN toxicity, with brain region effects reversing more quickly than muscle. In vivo monitoring of multiple organs may provide important clinical information regarding the extent of CN toxicity and subsequent recovery, and facilitate antidote drug development.",

keywords = "Brain, Cyanide antidote, Cyanide poisoning, Diffuse optical spectroscopy, Metabolism, Muscle, Sulfanegen sodium",

author = "Kim, {Jae G.} and Jangwoen Lee and Mahon, {Sari B.} and David Mukai and Patterson, {Steven E.} and Boss, {Gerry R.} and Tromberg, {Bruce J.} and Matthew Brenner",

note = "Funding Information: This work was supported by the AF [9550-04-1-0101, 9550-08-1-0384]; the Laser Microbeam and Medical Program from the National Center for Research Resources [P41RR001192]; the National Institutes of Health [1U54NS063718, U01-NS058030]; Basic research project and APRI-research program through grants provided by GIST, Korea. The authors thank David Yoon for his help in manuscript editing and preparation.",

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AU - Kim, Jae G.

AU - Lee, Jangwoen

AU - Mahon, Sari B.

AU - Mukai, David

AU - Patterson, Steven E.

AU - Boss, Gerry R.

AU - Tromberg, Bruce J.

AU - Brenner, Matthew

N1 - Funding Information: This work was supported by the AF [9550-04-1-0101, 9550-08-1-0384]; the Laser Microbeam and Medical Program from the National Center for Research Resources [P41RR001192]; the National Institutes of Health [1U54NS063718, U01-NS058030]; Basic research project and APRI-research program through grants provided by GIST, Korea. The authors thank David Yoon for his help in manuscript editing and preparation.

PY - 2012/10

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N2 - Noninvasive near infrared spectroscopy measurements were performed to monitor cyanide (CN) poisoning and recovery in the brain region and in foreleg muscle simultaneously, and the effects of a novel CN antidote, sulfanegen sodium, on tissue hemoglobin oxygenation changes were compared using a sub-lethal rabbit model. The results demonstrated that the brain region is more susceptible to CN poisoning and slower in endogenous CN detoxification following exposure than peripheral muscles. However, sulfanegen sodium rapidly reversed CN toxicity, with brain region effects reversing more quickly than muscle. In vivo monitoring of multiple organs may provide important clinical information regarding the extent of CN toxicity and subsequent recovery, and facilitate antidote drug development.

AB - Noninvasive near infrared spectroscopy measurements were performed to monitor cyanide (CN) poisoning and recovery in the brain region and in foreleg muscle simultaneously, and the effects of a novel CN antidote, sulfanegen sodium, on tissue hemoglobin oxygenation changes were compared using a sub-lethal rabbit model. The results demonstrated that the brain region is more susceptible to CN poisoning and slower in endogenous CN detoxification following exposure than peripheral muscles. However, sulfanegen sodium rapidly reversed CN toxicity, with brain region effects reversing more quickly than muscle. In vivo monitoring of multiple organs may provide important clinical information regarding the extent of CN toxicity and subsequent recovery, and facilitate antidote drug development.

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KW - Cyanide antidote

KW - Cyanide poisoning

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KW - Metabolism

KW - Muscle

KW - Sulfanegen sodium

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Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism

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