Noninvasive pulse wave analysis for the early detection of vascular disease

Jay N Cohn, Stanley M Finkelstein, Gary McVeigh, Dennis Morgan, Lisa LeMay, Jennifer Robinson, James Mock

Research output: Contribution to journalArticlepeer-review

403 Scopus citations


A noninvasive technique has been developed and validated for calculating capacitive and oscillatory systemic arterial compliance with the use of pulse wave analysis and a modified Windkessel model. Application of the technique to subjects with hypertension, postmenopausal women with symptomatic coronary artery disease, and appropriate control subjects has confirmed a reduction of oscillatory compliance in the disease states and an increase in capacitive and oscillatory compliances in response to vasodilator drugs. This method should be useful in screening subjects for early evidence of vascular disease and in monitoring the response to therapy.

Original languageEnglish (US)
Pages (from-to)503-508
Number of pages6
Issue number3
StatePublished - Sep 1995


  • arterial compliance
  • atherosclerosis
  • cardiac output
  • hypertension
  • vasodilation drugs


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