Noninvasive three-dimensional cardiac activation imaging of ventricular arrhythmias in the rabbit heart

Chengzong Han, Steven M. Pogwizd, Cheryl R. Killingsworth, Jiajie Yan, Bin He

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

In the present study, a physical-model based threedimensional (3-D) cardiac electrical imaging (3-DCEI) technique was evaluated with the aid of 3-D intra-cardiac mapping from 200 intramural sites during norepinephrine (NE) induced ventricular arrhythmias in the rabbit heart. Body surface potentials and intramural bipolar electrical recordings using plunge-needle electrodes were simultaneously measured in a closedchest condition in a healthy rabbit. The non-invasively imaged activation sequence correlated well with invasively easured counterparts, with an averaged correlation coefficient of 0.70, and a relative error of 0.30. The sites of initial activation were well localized to be within ∼5mm from the initiation sites determined from intra-cardiac mapping. The present experimental results suggest that the 3-DCEI approach can reconstruct 3-D ventricular global activation sequence and localize the origin of activation during focal ventricular arrhythmias.

Original languageEnglish (US)
Title of host publicationComputing in Cardiology 2010, CinC 2010
Pages125-127
Number of pages3
StatePublished - 2010
EventComputing in Cardiology 2010, CinC 2010 - Belfast, United Kingdom
Duration: Sep 26 2010Sep 29 2010

Publication series

NameComputing in Cardiology
Volume37
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X

Other

OtherComputing in Cardiology 2010, CinC 2010
CountryUnited Kingdom
CityBelfast
Period9/26/109/29/10

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