Normal and metastatic melanin in the temporal bone

Claudia M. Navarrete, Carlos B. Ruah, Patricia Schachern, Michael M. Paparella

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Purpose: Malignant melanoma is known to metastasize to the temporal bone. However, melanocytes exist in the normal inner ear and may be difficult to distinguish from metastatic melanotic cells. This study describes distribution of normal melanin in the ear and metastatic melanoma to the temporal bone. Materials and Methods: Normal melanin distribution is described in 48 temporal bones from White (18), Native-American (19), and African-American (11) individuals and metastatic melanoma to the temporal bone is described in four cases (seven temporal bones). Temporal bones were removed at autopsy, fixed in 10% buffered formalin, and processed for routine celloidin embedding. Sections were cut at a thickness of 20 μm and every tenth section was stained with hematoxylin-eosin for light microscopic evaluation. Results: Normal melanin was found in the inner ear, mainly around terminal neural structures and blood vessels, and occurred in greater quantities in African-American individuals. Metastatic melanotic cells reached the temporal bone by hematological dissemination, and by neural invasion from the central nervous system. No correlation was found between histopathological findings and clinical symptoms of patients. Conclusions: Metastatic melanoma to the temporal bone may be seen in the same areas as normal melanin. They may also be observed in bone marrow cells of the petrous bone and along the course of nerves of the internal auditory canal and cochlear vestibular labyrinth, either by following neural sheaths or blood vessels that run along the nerve. Metastatic disease to the temporal bone is often asymptomatic, or it may present with uncharacteristic symptoms that may delay diagnosis.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalAmerican Journal of Otolaryngology--Head and Neck Medicine and Surgery
Volume16
Issue number1
DOIs
StatePublished - Jan 1 1995

Bibliographical note

Funding Information:
From the Otitis Media Research Center, Otopathology Laboratory, Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, MN; the Minnesota Ear, Head and Neck Clinic, Minneapolis, MN; the Clinica ORL LDA, Lisbon, Portugal; and the University of Conception, Conception, Chile. Supported by National Institutes of Health NIDCD Grant No. P50-DC-00133 and the International Hearing Foundation. Address reprint requests to Patricia Schachern, Department of Otolaryngology, 2630 University Ave SE, Minneapolis, MN 55414. Copyright 0 1995 by W.B. Saunders Company 0196-0709/95/l 601-0006$5.00/0

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