Normal formation and repair of γ-radiation-induced single and double strand DNA breaks in Down syndrome fibroblasts

Marie E. Steiner; William G. Woods

doi:10.1016/0027-5107(82)90282-2

Normal formation and repair of γ-radiation-induced single and double strand DNA breaks in Down syndrome fibroblasts

Marie E. Steiner, William G. Woods

Pediatrics - Hematology

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Abstract

Fibroblasts from patients with Down syndrome (Trisomy 21) were examined for repair capability of γ-radiation-induced single strand and double strand DNA breaks. Formation and repair of DNA breaks were determined by DNA alkaline and non-denaturing elution techniques. Down syndrome fibroblasts were found to repair single strand and double strand breaks as well as fibroblasts from normal controls.

Original language	English (US)
Pages (from-to)	515-523
Number of pages	9
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	95
Issue number	2-3
DOIs	https://doi.org/10.1016/0027-5107(82)90282-2
State	Published - Aug 1982

Bibliographical note

Funding Information:
Supported in part by grants from the University of Minnesota Graduate School, American Cancer Society (ACS IN 13-S-59), Minnesota Medical Foundation, and March of Dimes Summer Science Research Program for Medical Students. Dr. Woods is a recipient of a Junior Faculty Clinical Fellowship from the American Cancer Society.

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AU - Woods, William G.

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N2 - Fibroblasts from patients with Down syndrome (Trisomy 21) were examined for repair capability of γ-radiation-induced single strand and double strand DNA breaks. Formation and repair of DNA breaks were determined by DNA alkaline and non-denaturing elution techniques. Down syndrome fibroblasts were found to repair single strand and double strand breaks as well as fibroblasts from normal controls.

AB - Fibroblasts from patients with Down syndrome (Trisomy 21) were examined for repair capability of γ-radiation-induced single strand and double strand DNA breaks. Formation and repair of DNA breaks were determined by DNA alkaline and non-denaturing elution techniques. Down syndrome fibroblasts were found to repair single strand and double strand breaks as well as fibroblasts from normal controls.

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Normal formation and repair of γ-radiation-induced single and double strand DNA breaks in Down syndrome fibroblasts

Abstract

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