Normal formation and repair of γ-radiation-induced single and double strand DNA breaks in Down syndrome fibroblasts

Marie E. Steiner, William G. Woods

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Fibroblasts from patients with Down syndrome (Trisomy 21) were examined for repair capability of γ-radiation-induced single strand and double strand DNA breaks. Formation and repair of DNA breaks were determined by DNA alkaline and non-denaturing elution techniques. Down syndrome fibroblasts were found to repair single strand and double strand breaks as well as fibroblasts from normal controls.

Original languageEnglish (US)
Pages (from-to)515-523
Number of pages9
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume95
Issue number2-3
DOIs
StatePublished - Aug 1982

Bibliographical note

Funding Information:
Supported in part by grants from the University of Minnesota Graduate School, American Cancer Society (ACS IN 13-S-59), Minnesota Medical Foundation, and March of Dimes Summer Science Research Program for Medical Students. Dr. Woods is a recipient of a Junior Faculty Clinical Fellowship from the American Cancer Society.

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