Abstract
A series of novel indole-3-carboxaldehyde conjugated with different aryl amines were synthesized and examined for their antioxidant potential to probe the most potent analogues using two in vitro models like 2,2-diphenyl-1- picrylhydrazyl (DPPH) free radical scavenging assay and inhibition of microsomal lipid peroxidation (LPO) assay. Through the compounds showed various degree of activity whereas, compound (5f) displayed superior antioxidant activity relative to other examined analogues and also exhibit more activity than the standard, butylated hydroxy anisole (BHA).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 783-790 |
| Number of pages | 8 |
| Journal | Der Pharma Chemica |
| Volume | 4 |
| Issue number | 2 |
| State | Published - Aug 15 2012 |
Keywords
- Antioxidant activity
- Aryl amines
- Free radical scavenging
- Indole-3-carboxaldehyde
- Microsomal lipid peroxidation