Novel mycophenolic adenine bis(phosphonate)s as potent anticancer agents and inducers of cells differentiation

Krzysztof W. Pankiewicz; Krystyna Lesiak-Watanabe

doi:10.1080/15257779908041601

Novel mycophenolic adenine bis(phosphonate)s as potent anticancer agents and inducers of cells differentiation

Krzysztof W. Pankiewicz, Krystyna Lesiak-Watanabe

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

An effective treatment of myeloid leukemias would rely on inducing myeloid cells to undergo differentiation. It has been demonstrated that inhibition of IMPDH with mycophenolic acid or tiazofurin resulted in inhibition of cell growth as well as induction of differentiation. We synthesized a number of bis(phosphonate) analogues of tiazofurin-, benzamide- , and mycophenolic-adenine dinucleotide which were found to be cytotoxic as well as effective inducers of cell differentiation.

Original language	English (US)
Pages (from-to)	927-932
Number of pages	6
Journal	Nucleosides and Nucleotides
Volume	18
Issue number	4-5
DOIs	https://doi.org/10.1080/15257779908041601
State	Published - 1999

Bibliographical note

Funding Information:
ACKNOWLEDGMENT The authors thanks Dr. Takashi Tsuji of Aijnomoto Co., Inc., Japan for a gift of mycophenolic acid. We also thank Dr. Koyichi A. Watanabe of Codon Pharmaceuticals, Inc., for his continued interest. This work was supported by NIH grant lR43GM54503-01A2

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title = "Novel mycophenolic adenine bis(phosphonate)s as potent anticancer agents and inducers of cells differentiation",

abstract = "An effective treatment of myeloid leukemias would rely on inducing myeloid cells to undergo differentiation. It has been demonstrated that inhibition of IMPDH with mycophenolic acid or tiazofurin resulted in inhibition of cell growth as well as induction of differentiation. We synthesized a number of bis(phosphonate) analogues of tiazofurin-, benzamide- , and mycophenolic-adenine dinucleotide which were found to be cytotoxic as well as effective inducers of cell differentiation.",

author = "Pankiewicz, {Krzysztof W.} and Krystyna Lesiak-Watanabe",

note = "Funding Information: ACKNOWLEDGMENT The authors thanks Dr. Takashi Tsuji of Aijnomoto Co., Inc., Japan for a gift of mycophenolic acid. We also thank Dr. Koyichi A. Watanabe of Codon Pharmaceuticals, Inc., for his continued interest. This work was supported by NIH grant lR43GM54503-01A2",

year = "1999",

doi = "10.1080/15257779908041601",

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T1 - Novel mycophenolic adenine bis(phosphonate)s as potent anticancer agents and inducers of cells differentiation

AU - Pankiewicz, Krzysztof W.

AU - Lesiak-Watanabe, Krystyna

N1 - Funding Information: ACKNOWLEDGMENT The authors thanks Dr. Takashi Tsuji of Aijnomoto Co., Inc., Japan for a gift of mycophenolic acid. We also thank Dr. Koyichi A. Watanabe of Codon Pharmaceuticals, Inc., for his continued interest. This work was supported by NIH grant lR43GM54503-01A2

PY - 1999

Y1 - 1999

N2 - An effective treatment of myeloid leukemias would rely on inducing myeloid cells to undergo differentiation. It has been demonstrated that inhibition of IMPDH with mycophenolic acid or tiazofurin resulted in inhibition of cell growth as well as induction of differentiation. We synthesized a number of bis(phosphonate) analogues of tiazofurin-, benzamide- , and mycophenolic-adenine dinucleotide which were found to be cytotoxic as well as effective inducers of cell differentiation.

AB - An effective treatment of myeloid leukemias would rely on inducing myeloid cells to undergo differentiation. It has been demonstrated that inhibition of IMPDH with mycophenolic acid or tiazofurin resulted in inhibition of cell growth as well as induction of differentiation. We synthesized a number of bis(phosphonate) analogues of tiazofurin-, benzamide- , and mycophenolic-adenine dinucleotide which were found to be cytotoxic as well as effective inducers of cell differentiation.

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Novel mycophenolic adenine bis(phosphonate)s as potent anticancer agents and inducers of cells differentiation

Abstract

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