Novel, orally effective cyanide antidotes

Herbert T. Nagasawa; David J.W. Goon; Daune L. Crankshaw; Robert Vince; Steven E. Patterson

doi:10.1021/jm7011497

Novel, orally effective cyanide antidotes

Herbert T. Nagasawa, David J.W. Goon, Daune L. Crankshaw, Robert Vince, Steven E. Patterson

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

A series of prodrugs of 3-mercaptopyruvate (3-MP), the substrate for the enzyme 3-mercaptopyruvate/cyanide sulfurtransferase (3-MPST) that converts cyanide to the nontoxic thiocyanate, which are highly effective cyanide antidotes, have been developed. These prodrugs of 3-MP are unique in being not only orally bioavailable, but may be administered up to an hour prior to cyanide as a prophylactic agent and are both rapid- or slow-acting when given parenterally.

Original language	English (US)
Pages (from-to)	6462-6464
Number of pages	3
Journal	Journal of medicinal chemistry
Volume	50
Issue number	26
DOIs	https://doi.org/10.1021/jm7011497
State	Published - Dec 27 2007

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AU - Nagasawa, Herbert T.

AU - Goon, David J.W.

AU - Crankshaw, Daune L.

AU - Vince, Robert

AU - Patterson, Steven E.

PY - 2007/12/27

Y1 - 2007/12/27

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AB - A series of prodrugs of 3-mercaptopyruvate (3-MP), the substrate for the enzyme 3-mercaptopyruvate/cyanide sulfurtransferase (3-MPST) that converts cyanide to the nontoxic thiocyanate, which are highly effective cyanide antidotes, have been developed. These prodrugs of 3-MP are unique in being not only orally bioavailable, but may be administered up to an hour prior to cyanide as a prophylactic agent and are both rapid- or slow-acting when given parenterally.

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Novel, orally effective cyanide antidotes

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