Novel, orally effective cyanide antidotes

Herbert T. Nagasawa, David J.W. Goon, Daune L. Crankshaw, Robert Vince, Steven E. Patterson

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

A series of prodrugs of 3-mercaptopyruvate (3-MP), the substrate for the enzyme 3-mercaptopyruvate/cyanide sulfurtransferase (3-MPST) that converts cyanide to the nontoxic thiocyanate, which are highly effective cyanide antidotes, have been developed. These prodrugs of 3-MP are unique in being not only orally bioavailable, but may be administered up to an hour prior to cyanide as a prophylactic agent and are both rapid- or slow-acting when given parenterally.

Original languageEnglish (US)
Pages (from-to)6462-6464
Number of pages3
JournalJournal of medicinal chemistry
Volume50
Issue number26
DOIs
StatePublished - Dec 27 2007

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