Nutrition, DNA methylation, and developmental origins of cardiometabolic disease: A signal systems approach

Zachary M. Laubach, Christopher D. Faulk, Andres Cardenas, Wei Perng

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The developmental origins of health and disease (DOHaD) hypothesis posits that environmental exposures during vulnerable developmental stages have a lasting impact on adult phenotype. Early life nutrition is recognized as a key determinant of long-term health, and epigenetic mechanisms have surfaced as a potential biological mechanism. This review first provides an overview of literature regarding epigenetically mediated DOHaD phenomena within the realm of cardiometabolic disease. Next, parallels are drawn between a signal system and epigenetic programming in DOHaD; specifically, with DNA methylation acting as a signal within an individual spanning from early to later life. Finally, epigenetically mediated DOHaD phenomena are explored using life course epidemiology and a signal system framework to identify potential sources of error, and make suggestions for appropriate study designs and analytical strategies.

Original languageEnglish (US)
Title of host publicationHandbook of Nutrition, Diet, and Epigenetics
PublisherSpringer International Publishing
Pages43-60
Number of pages18
Volume1
ISBN (Electronic)9783319555300
ISBN (Print)9783319555294
DOIs
StatePublished - Jan 5 2019

Keywords

  • DNA Methylation
  • DOHaD
  • Drift
  • Epigenetics
  • Metabolic risk
  • Nutrition
  • Signal system

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