Nutrition, DNA methylation, and developmental origins of cardiometabolic disease: A signal systems approach

Zachary M. Laubach; Christopher D. Faulk; Andres Cardenas; Wei Perng

doi:10.1007/978-3-319-55530-0_107

Nutrition, DNA methylation, and developmental origins of cardiometabolic disease: A signal systems approach

Zachary M. Laubach, Christopher D. Faulk, Andres Cardenas, Wei Perng

Animal Science

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Abstract

The developmental origins of health and disease (DOHaD) hypothesis posits that environmental exposures during vulnerable developmental stages have a lasting impact on adult phenotype. Early life nutrition is recognized as a key determinant of long-term health, and epigenetic mechanisms have surfaced as a potential biological mechanism. This review first provides an overview of literature regarding epigenetically mediated DOHaD phenomena within the realm of cardiometabolic disease. Next, parallels are drawn between a signal system and epigenetic programming in DOHaD; specifically, with DNA methylation acting as a signal within an individual spanning from early to later life. Finally, epigenetically mediated DOHaD phenomena are explored using life course epidemiology and a signal system framework to identify potential sources of error, and make suggestions for appropriate study designs and analytical strategies.

Original language	English (US)
Title of host publication	Handbook of Nutrition, Diet, and Epigenetics
Publisher	Springer International Publishing
Pages	43-60
Number of pages	18
Volume	1
ISBN (Electronic)	9783319555300
ISBN (Print)	9783319555294
DOIs	https://doi.org/10.1007/978-3-319-55530-0_107
State	Published - Jan 5 2019

Keywords

DNA Methylation
DOHaD
Drift
Epigenetics
Metabolic risk
Nutrition
Signal system

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Nutrition, DNA methylation, and developmental origins of cardiometabolic disease: A signal systems approach

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