Of mice, dirty mice, and men: Using mice to understand human immunology

David Masopust; Christine P. Sivula; Stephen C. Jameson

doi:10.4049/jimmunol.1700453

Of mice, dirty mice, and men: Using mice to understand human immunology

David Masopust, Christine P. Sivula, Stephen C. Jameson

Research output: Contribution to journal › Review article › peer-review

178 Scopus citations

Abstract

Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice versus humans. Opportunities are discussed for extending the predictive translational value of mouse research, with an emphasis on exploitation of a "dirty" mouse model that better mimics the diverse infectious history that is typical of most humans.

Original language	English (US)
Pages (from-to)	383-388
Number of pages	6
Journal	Journal of Immunology
Volume	199
Issue number	2
DOIs	https://doi.org/10.4049/jimmunol.1700453
State	Published - Jul 15 2017

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health Grants R01AI084913 (to D.M.) and R01AI116678 (to S.J.C.).

Publisher Copyright:
© 2017 by The American Association of Immunologists, Inc.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512602

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Of mice, dirty mice, and men: Using mice to understand human immunology

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