Of mice, dirty mice, and men: Using mice to understand human immunology

David Masopust, Christine P. Sivula, Stephen C. Jameson

Research output: Contribution to journalReview articlepeer-review

71 Scopus citations

Abstract

Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice versus humans. Opportunities are discussed for extending the predictive translational value of mouse research, with an emphasis on exploitation of a "dirty" mouse model that better mimics the diverse infectious history that is typical of most humans.

Original languageEnglish (US)
Pages (from-to)383-388
Number of pages6
JournalJournal of Immunology
Volume199
Issue number2
DOIs
StatePublished - Jul 15 2017

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health Grants R01AI084913 (to D.M.) and R01AI116678 (to S.J.C.).

Publisher Copyright:
© 2017 by The American Association of Immunologists, Inc.

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