Off-line recording and analysis of Doppler velocity waveform data

Meghan L. Thorne, Richard N. Rankin, Hristo N. Nikolov, David W. Holdsworth

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Doppler ultrasound velocity measurements are commonly used to diagnose atherosclerotic carotid artery disease. However, current Doppler techniques exhibit limitations with respect to sensitivity and specificity. We believe that advanced spectral analysis - including quantification of turbulence - could increase the diagnostic accuracy of duplex Doppler ultrasound. Routine application of advanced spectral analysis requires a practical technique to acquire and analyze the Doppler signal, which is compatible with clinical ultrasound machines. We describe the implementation of a technique for offline Doppler waveform analysis of carotid artery blood flow, using a portable MP3 recorder and custom analysis software. Forward and reverse audio signals were recorded with compression at 128 bps at prescribed points throughout the carotid bifurcation of human volunteers. Each data set was digitized at 44.1kHz and analyzed to produce velocity spectra at 12 ms intervals. From these instantaneous spectra, advanced Doppler indices of mean velocity and Fourier-based turbulence intensity (TI) were calculated. We found that MP3 compression had a negligible effect on the calculation of mean velocity data (0.17%) and TI (0.5%). We also found that Fourier-based TI was comparable to TI calculated by ensemble average. Finally, we were successful in applying this technique in vivo and demonstrated that long acquisitions and repeated measurements were possible in human volunteers. Our study demonstrates that it is feasible to acquire Doppler audio data using an MP3 recording device for off-line analysis, while only adding a short time to a conventional carotid exam.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2007
Subtitle of host publicationUltrasonic Imaging and Signal Processing
DOIs
StatePublished - Oct 15 2007
EventMedical Imaging 2007: Ultrasonic Imaging and Signal Processing - San Diego, CA, United States
Duration: Feb 18 2007Feb 19 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6513
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2007: Ultrasonic Imaging and Signal Processing
CountryUnited States
CitySan Diego, CA
Period2/18/072/19/07

Keywords

  • Blood-flow velocity
  • Carotid artery bifurcation
  • Doppler ultrasound
  • High-pass Butterworth filter
  • In vitro modeling
  • In vivo measurements
  • MP3 compression
  • Turbulence intensity

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