Abstract
Background: microRNAs (miRNAs) are crucially important in the development of cancer. Their dysregulation, commonly observed in various types of cancer, is largely cancer-dependent. Thus, to understand the tumor biology and to develop accurate and sensitive biomarkers, we need to understand pan-cancer miRNA expression. Constructions: At the University of Minnesota, we developed the OncomiR Cancer Database (OMCD), hosted on a web server, which allows easy and systematic comparative genomic analyses of miRNA sequencing data derived from more than 9500 cancer patients tissue samples available in the Cancer Genome Atlas (TCGA). OMCD includes associated clinical information and is searchable by organ-specific terms common to the TCGA. Conclusions: Freely available to all users (www.oncomir.umn.edu/omcd/), OMCD enables (1) simple visualization of TCGA miRNA sequencing data, (2) statistical analysis of differentially expressed miRNAs for each cancer type, and (3) exploration of miRNA clusters across cancer types.
| Original language | English (US) |
|---|---|
| Article number | 1223 |
| Journal | BMC Cancer |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 6 2018 |
Bibliographical note
Funding Information:ALS and SS are supported by research grants funded by the National Cancer Institute of the National Institutes of Health, numbers R50 CA211249 and R03CA219129 respectively; CY, by the MnDrive - University of Minnesota Informatics Institute graduate fellowship.
Publisher Copyright:
© 2018 The Author(s).
Keywords
- Cancer
- Database
- OncomiR
- TCGA
- miRNA
- miRNA expression profile
- microRNA
