Abstract
In this article we (1) outline the construction of a 3-D "graphical" representation of DNA primary sequences, illustrated on a portion of the human β globin gene; (2) describe a particular scheme that transforms the above 3-D spatial representation of DNA into a numerical matrix representation; (3) illustrate construction of matrix invariants for DNA sequences; and (4) suggest a data reduction based on statistical analysis of matrix invariants generated for DNA. Each of the four contributions represents a novel development that we hope will facilitate comparative studies of DNA and open new directions for representation and characterization of DNA primary sequences.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1235-1244 |
| Number of pages | 10 |
| Journal | Journal of chemical information and computer sciences |
| Volume | 40 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 2000 |