On- and off-resonance T1ρ MRI in acute cerebral ischemia of the rat

Olli H.J. Gröhn; Heidi I. Mäkelä; Jouko A. Lukkarinen; Lance DelaBarre; Joseph Lin; Michael Garwood; Risto A. Kauppinen

doi:10.1002/mrm.10356

On- and off-resonance T_1ρ MRI in acute cerebral ischemia of the rat

Olli H.J. Gröhn, Heidi I. Mäkelä, Jouko A. Lukkarinen, Lance DelaBarre, Joseph Lin, Michael Garwood, Risto A. Kauppinen

Center for Magnetic Resonance Research

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The ability of on-resonance T_1ρ (T_1ρ) and off-resonance T_1ρ (T_1ρ^off) measurements to indicate acute cerebral ischemia in a rat model of transient middle cerebral artery (MCA) occlusion was investigated at 4.7 T. T_1ρ was determined with B₁ fields of 0.4, 0.8, and 1.6 G, and T_1ρ^off with five offset frequencies (Δω) ranging from 0-7.5 kHz at B₁ of 0.4 G, yielding effective B₁ (B_eff) from 0.4 to 1.8 G. Diffusion, T₁, and T₂ were also quantified. Both T_1ρ and T_1ρ^off acquired with Δo < 2.5 kHz showed positive contrast during the first hours of MCA occlusion in the ischemic tissue delineated by low diffusion. Interestingly, T_1ρ^off contrast acquired with Δω > 2.5 kHz was clearly less sensitive to ischemic alterations, and developed with a delayed time course. This discrepancy is thought to be a consequence of the frequency dependency of cross-relaxation during irradiation with spin-lock pulses.

Original language	English (US)
Pages (from-to)	172-176
Number of pages	5
Journal	Magnetic resonance in medicine
Volume	49
Issue number	1
DOIs	https://doi.org/10.1002/mrm.10356
State	Published - Jan 1 2003

Keywords

Brain
Ischemia
Relaxation
Spin-lock
T

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abstract = "The ability of on-resonance T1ρ (T1ρ) and off-resonance T1ρ (T1ρoff) measurements to indicate acute cerebral ischemia in a rat model of transient middle cerebral artery (MCA) occlusion was investigated at 4.7 T. T1ρ was determined with B1 fields of 0.4, 0.8, and 1.6 G, and T1ρoff with five offset frequencies (Δω) ranging from 0-7.5 kHz at B1 of 0.4 G, yielding effective B1 (Beff) from 0.4 to 1.8 G. Diffusion, T1, and T2 were also quantified. Both T1ρ and T1ρoff acquired with Δo < 2.5 kHz showed positive contrast during the first hours of MCA occlusion in the ischemic tissue delineated by low diffusion. Interestingly, T1ρoff contrast acquired with Δω > 2.5 kHz was clearly less sensitive to ischemic alterations, and developed with a delayed time course. This discrepancy is thought to be a consequence of the frequency dependency of cross-relaxation during irradiation with spin-lock pulses.",

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AU - Lin, Joseph

AU - Garwood, Michael

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