Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense potential to deliver targeted therapy. Here, we review a wide range of strategies that have been tried, tested, and demonstrated to enhance the specificity of oncolytic viruses towards specific cancer cells. A combination of these strategies and other conventional therapies may be more effective than any of those strategies alone.
Bibliographical noteFunding Information:
The works were partly supported by NIH/NCI awards (R01CA196215, R01CA168448, and R01CA228760).
Funding: The works were partly supported by NIH/NCI R01CA228760)
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
- Adenovirus vector
- Oncolytic adenovirus
PubMed: MeSH publication types
- Journal Article