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Abstract
A new reactive oxygen species (ROS)-sensitive, self-immolative biodegradable polyoxalate prodrug based on the anticancer chemotherapeutic hormone analog diethylstilbestrol was synthesized via one-pot step-growth polymerization. The nanoparticles prepared from this prodrug undergo self-immolative degradation releasing the chemotherapeutic drug in ROS-rich environments, e.g., in cancer cells. This new ROS self-immolative polyprodrug backbone eliminates the need for a linker between polymer chain and drug, resulting in a more specific drug release and minimized toxic side effects to non-ROS-producing cells as proven by in vitro experiments. The strategy enables re-utilization of a successful chemotherapeutic agent that has been clinically under-utilized due to dose-related side effects.
Original language | English (US) |
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Pages (from-to) | 1999-2004 |
Number of pages | 6 |
Journal | Polymer Chemistry |
Volume | 8 |
Issue number | 13 |
DOIs | |
State | Published - Apr 7 2017 |
Bibliographical note
Funding Information:The financial support of the Ministry of Education, Youth and Sports (grants # LH14079, POLYMAT #LO1507), the Czech Science Foundation (grant # 16-02870S, 15-13853S and 17-09998S), and the National Science Foundation through the University of Minnesota MRSEC, Award DMR-1420013 is gratefully appreciated.
Publisher Copyright:
© 2017 The Royal Society of Chemistry.
How much support was provided by MRSEC?
- Partial
Reporting period for MRSEC
- Period 3
Fingerprint
Dive into the research topics of 'One-pot synthesis of reactive oxygen species (ROS)-self-immolative polyoxalate prodrug nanoparticles for hormone dependent cancer therapy with minimized side effects'. Together they form a unique fingerprint.-
MRSEC IRG-3: Hierarchical Multifunctional Macromolecular Materials
Reineke, T. M., Bates, F. S., Dorfman, K., Dutcher, C. S., Hillmyer, M. A., Lodge, T., Morse, D. C., Siepmann, I., Barreda, L. & Ganewatta, M. S.
1/1/98 → …
Project: Research project
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