Optimization of the reduction of 74 As(V) to 74 As(III) and of the labelling of dithiol dihydrolipoic acid

Zita Oláh, Andreas T.J. Vogg, Tibor Kremmer, Zoltán Szűcs, Zoltán Varga, Rita Dóczi

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Abstract

The radiochemical separation of n.c.a. arsenic on its own or for radio-labelling purposes usually involves the issue of reducing arsenic(V). Numerous approaches for reducing pentavalent arsenic have been examined. A novel HPLC method has also been presented for accessing the efficiency of the reduction in terms of *As(III)/*As(V). Labelling with trivalent radioarsenic seems to be a promising research field to access new radiopharmaceuticals, for example, using arsenic as a surrogate for phosphorus. Moreover, as a model system, the labelling reaction of *As(III) with dihydrolipoic acid has been systematically optimized.

Original languageEnglish (US)
Pages (from-to)75-82
Number of pages8
JournalApplied Radiation and Isotopes
Volume149
DOIs
StatePublished - Jul 2019
Externally publishedYes

Bibliographical note

Funding Information:
This work was partly and jointly supported by NKFI (Hungary, grant TET_12_DE-I-2013-0013 ) and BMBF (Germany, grant 01DS14024 ).

Funding Information:
We thank to Prof. Dr. B. Neumaier and Dr. I. Spahn from the Research Centre Jülich, Institute for Neurosciences and Medicine, section Nuclear Chemistry (INM-5), for providing proton irradiated nat.GeO2 pellets containing 74As. This work was partly and jointly supported by NKFI (Hungary, grant TET_12_DE-I-2013-0013) and BMBF (Germany, grant 01DS14024).

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