Optofluidic lasers with a single molecular layer of gain

Qiushu Chen, Michael Ritt, Sivaraj Sivaramakrishnan, Yuze Sun, Xudong Fan

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


We achieve optofluidic lasers with a single molecular layer of gain, in which green fluorescent protein, dye-labeled bovine serum albumin, and dye-labeled DNA, are used as the gain medium and attached to the surface of a ring resonator via surface immobilization biochemical methods. It is estimated that the surface density of the gain molecules is on the order of 1012 cm-2, sufficient for lasing under pulsed optical excitation. It is further shown that the optofluidic laser can be tuned by energy transfer mechanisms through biomolecular interactions. This work not only opens a door to novel photonic devices that can be controlled at the level of a single molecular layer but also provides a promising sensing platform to analyze biochemical processes at the solid-liquid interface.

Original languageEnglish (US)
Pages (from-to)4590-4595
Number of pages6
JournalLab on a chip
Issue number24
StatePublished - Dec 21 2014

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2014.


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