Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine

Wim Derave; Els Vanden Eede; Peter Hespel; Steven G. Carmella; Stephen S. Hecht

doi:10.1016/j.nut.2005.10.004

Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine

Wim Derave, Els Vanden Eede, Peter Hespel, Steven G. Carmella, Stephen S. Hecht

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Abstract

Objective: Creatine is a popular oral supplement in athletes and may have therapeutical potential in neuromuscular diseases. It has been hypothesized that creatine ingestion can lead to increased formation of the carcinogen N-nitrososarcosine. Methods: We investigated in a double-blind, placebo-controlled study the urinary excretion of N-nitrososarcosine after 1-wk high-dose (20 g/d) and 20-wk low-dose (5 g/d) creatine supplementation in healthy humans. Results and conclusion: Creatine ingestion does not systematically increase urinary N-nitrososarcosine excretion.

Original language	English (US)
Pages (from-to)	332-333
Number of pages	2
Journal	Nutrition
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/j.nut.2005.10.004
State	Published - Mar 2006

Keywords

Cancer
Nitrite
Nutritional supplement

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine",

abstract = "Objective: Creatine is a popular oral supplement in athletes and may have therapeutical potential in neuromuscular diseases. It has been hypothesized that creatine ingestion can lead to increased formation of the carcinogen N-nitrososarcosine. Methods: We investigated in a double-blind, placebo-controlled study the urinary excretion of N-nitrososarcosine after 1-wk high-dose (20 g/d) and 20-wk low-dose (5 g/d) creatine supplementation in healthy humans. Results and conclusion: Creatine ingestion does not systematically increase urinary N-nitrososarcosine excretion.",

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doi = "10.1016/j.nut.2005.10.004",

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T1 - Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine

AU - Derave, Wim

AU - Vanden Eede, Els

AU - Hespel, Peter

AU - Carmella, Steven G.

AU - Hecht, Stephen S.

PY - 2006/3

Y1 - 2006/3

N2 - Objective: Creatine is a popular oral supplement in athletes and may have therapeutical potential in neuromuscular diseases. It has been hypothesized that creatine ingestion can lead to increased formation of the carcinogen N-nitrososarcosine. Methods: We investigated in a double-blind, placebo-controlled study the urinary excretion of N-nitrososarcosine after 1-wk high-dose (20 g/d) and 20-wk low-dose (5 g/d) creatine supplementation in healthy humans. Results and conclusion: Creatine ingestion does not systematically increase urinary N-nitrososarcosine excretion.

AB - Objective: Creatine is a popular oral supplement in athletes and may have therapeutical potential in neuromuscular diseases. It has been hypothesized that creatine ingestion can lead to increased formation of the carcinogen N-nitrososarcosine. Methods: We investigated in a double-blind, placebo-controlled study the urinary excretion of N-nitrososarcosine after 1-wk high-dose (20 g/d) and 20-wk low-dose (5 g/d) creatine supplementation in healthy humans. Results and conclusion: Creatine ingestion does not systematically increase urinary N-nitrososarcosine excretion.

KW - Cancer

KW - Nitrite

KW - Nutritional supplement

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Oral creatine supplementation in humans does not elevate urinary excretion of the carcinogen N-nitrososarcosine

Abstract

Keywords

UN SDGs

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