@inbook{4bc7386e25c1489d9de108d3be9eaa0e,
title = "Organ-On-A-Chip in vitro Models of the Brain and the Blood-Brain Barrier and Their Value to Study the Microbiota-Gut-Brain Axis in Neurodegeneration.",
abstract = "In an era of ecosystem degradation and climate change, maximizing microbial functions in agroecosystems has become a prerequisite for the future of global agriculture. However, managing species-rich communities of plant-associated microbiomes remains a major challenge. Here, we propose interdisciplinary research strategies to optimize microbiome functions in agroecosystems. Informatics now allows us to identify members and characteristics of 'core microbiomes', which may be deployed to organize otherwise uncontrollable dynamics of resident microbiomes. Integration of microfluidics, robotics and machine learning provides novel ways to capitalize on core microbiomes for increasing resource-efficiency and stress-resistance of agroecosystems.",
keywords = "16S, 80 and over, Acute Kidney Injury, Adaptation, Adaptive Immunity, Adult, Age Factors, Aged, Aging, Agricultural, Agriculture, Air Pollutants, Airway Management, Allergy and Immunology, Amniotic Fluid, Amphibians, Anaerobic, Anastomotic Leak, Animal, Animals, Antarctic Regions, Anthozoa, Anti-Bacterial Agents, Anti-Infective Agents, Anti-Inflammatory Agents, Anti-Retroviral Agents, Antibodies, Antidepressive Agents, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Antipsychotic Agents, Antirheumatic Agents, Antitubercular Agents, Aptamers, Arthritis, Artificial, Artificial Cells, Artificial Intelligence, Assisted, Asthma, Atomic Force, Atopic, Autism Spectrum Disorder, Autoimmune Diseases, Autoimmunity, Automation, Axenic Culture, Bacteria, Bacterial, Bacterial Adhesion, Bacterial Infections, Bacterial Physiological Phenomena, Bacterial Proteins, Bacterial Toxins, Bacterial Translocation, Bacterial Typing Techniques, Bacteriological Techniques, Bacteroidetes, Base Sequence, Bees, Behavior, Behcet Syndrome, Bifidobacterium, Biocatalysis, Biocompatible Materials, Biodegradation, Biodiversity, Bioengineering, Biofilms, Biological, Biological Assay, Biological Control Agents, Biological Evolution, Biological Factors, Biological Products, Biological Therapy, Biological Transport, Biological Variation, Biomarkers, Biomechanical Phenomena, Biomedical Research, Biomimetics, Bioreactors, Biosensing Techniques, Biotechnology, Birds, Blood Transfusion, Body Fluids, Botany, Brain, Breast Feeding, Breast Neoplasms, Buffers, CHO Cells, Caenorhabditis elegans, Capillary, Carbohydrate Metabolism, Carbon, Carbon Cycle, Carcinogenesis, Carcinoma, Cardiac Glycosides, Cardiovascular Diseases, Case-Control Studies, Cell Adhesion, Cell Biology, Cell Culture Techniques, Cell Differentiation, Cell Line, Cell Membrane, Cell Movement, Cell Physiological Phenomena, Cell Proliferation, Cell Separation, Cells, Cellular, Central Nervous System Diseases, Chemical, Chemotaxis, Chickens, Child, Child Development, Chronic Disease, Chronic Obstructive, Climate Change, Clinical Laboratory Techniques, Clinical Medicine, Clostridium Infections, Clostridium difficile, Coculture Techniques, Cognition, Cognitive Aging, Collodion, Colloids, Colorimetry, Computational Biology, Computer Simulation, Computer Systems, Conjunctiva, Consumer Product Safety, Coral Reefs, Cornea, Corynebacterium, Corynebacterium glutamicum, Cosmetics, Cricetinae, Crops, Cryptosporidium parvum, Culture, Cultured, Cyclic, Cystic Fibrosis, DNA, DNA Damage, DNA Transposable Elements, Databases, Dental Caries, Depressive Disorder, Dermatitis, Diabetes Mellitus, Diabetic Retinopathy, Diagnostic Equipment, Diagnostic Tests, Diet, Dietary Supplements, Diffusion, Digestive System Surgical Procedures, Dimethylpolysiloxanes, Directed Molecular Evolution, Disease, Disease Management, Disease Models, Disease Progression, Disease Susceptibility, Disease Transmission, Drosophila melanogaster, Drug Delivery Systems, Drug Design, Drug Development, Drug Discovery, Drug Evaluation, Drug Industry, Drug Resistance, Drug Utilization, Dysbiosis, Earth, Ecological and Environmental Phenomena, Ecology, Ecosystem, Education, Electric Impedance, Electric Power Supplies, Electrochemical Techniques, Electrodes, Electron, Electrophoresis, Embryo, Embryo Culture Techniques, Embryoid Bodies, Embryonic Development, Endocrine System, Endometrium, Endophytes, Energy Intake, Energy Metabolism, Environment, Environmental, Environmental Exposure, Environmental Microbiology, Environmental Monitoring, Enzymes, Epidemiologic Methods, Epidemiologic Studies, Epigenesis, Epigenomics, Epithelial Cells, Equipment Design, Erythrocytes, Escherichia coli, Essential, Estrogens, Evolution, Exercise, Eye, Eye Diseases, Factual, Fatty Acids, Fecal Microbiota Transplantation, Female, Fermentation, Fetal Development, Fetus, Firmicutes, Fishes, Flow Cytometry, Fluorescence, Fluorescent Dyes, Food Analysis, Food Contamination, Food Hypersensitivity, Food Microbiology, Food Quality, Food Safety, Food Technology, Foodborne Diseases, Forecasting, Frail Elderly, Free Radical Scavengers, Fungi, Gardnerella vaginalis, Gastrointestinal Microbiome, Gastrointestinal Tract, Gene Expression, Gene Expression Profiling, Gene Expression Regulation, Gene Regulatory Networks, Gene-Environment Interaction, Genes, Genetic, Genetic Engineering, Genetic Testing, Genetic Variation, Genetics, Genome, Genome-Wide Association Study, Genomics, Geography, Geriatric Assessment, Germ-Free Life, Giardia lamblia, Gingivitis, Glaucoma, Global Warming, Growth and Development, Guanosine Pentaphosphate, HIV Infections, Hazardous Substances, Health, Health Status, Healthy Volunteers, Heart Failure, Heavy, Helicobacter Infections, Helicobacter pylori, Hepatitis, High-Throughput Nucleotide Sequencing, High-Throughput Screening Assays, Holography, Homeostasis, Host Microbial Interactions, Host Specificity, Host-Pathogen Interactions, Human, Human Development, Humans, Hydra, Hydrocortisone, Hydrodynamics, Hydrogels, Hygiene Hypothesis, Hypersensitivity, Hypertension, Hypothalamo-Hypophyseal System, Image Cytometry, Immobilized, Immune Evasion, Immune System, Immune System Diseases, Immune Tolerance, Immunity, Immunoassay, Immunocompetence, Immunologic, Immunologic Factors, Immunological, Immunomagnetic Separation, Immunomodulation, Immunotherapy, In Situ Hybridization, Inactivation, Inappropriate Prescribing, Individual, Individuality, Indoles, Infant, Infection Control, Infections, Infectious, Infectious Disease Transmission, Inflammation, Inflammatory Bowel Diseases, Inhalation Exposure, Innate, Insecta, Insertional, Insulin Resistance, Intensive Care Units, Interstitial, Intestinal Mucosa, Intestines, Inventions, Iontophoresis, Irritable Bowel Syndrome, Isotope Labeling, Isotopes, Jurkat Cells, Ketogenic, Ketosis, Kinetics, Lab-On-A-Chip Devices, Laboratory, Lactobacillales, Lactobacillus, Laser Capture Microdissection, Life Style, Limit of Detection, Lipopolysaccharides, Liver, Liver Cirrhosis, Liver Diseases, Liver Regeneration, Locomotion, Longevity, Luminescent Agents, Luminescent Measurements, Luminescent Proteins, Lung, Lung Diseases, Lung Neoplasms, Lung Transplantation, Lymphocytes, Machine Learning, Macromolecular Substances, Macular Degeneration, Magnetics, Male, Malnutrition, Mammalian, Mammals, Mass Screening, Mass Spectrometry, Materials Testing, Mechanical, Medicinal, Melanoma, Membranes, Mental Disorders, Mesenchymal Stem Cells, Messenger, Metabolic, Metabolic Detoxication, Metabolic Diseases, Metabolic Engineering, Metabolic Networks and Pathways, Metabolism, Metabolome, Metabolomics, Metagenome, Metagenomics, Metals, Metformin, Methylamines, Mice, MicroRNAs, Microalgae, Microbial, Microbial Consortia, Microbial Interactions, Microbial Sensitivity Tests, Microbiological Phenomena, Microbiological Techniques, Microbiology, Microbiota, Microchemistry, Microfluidic Analytical Techniques, Microfluidics, Microscopy, Microspheres, Microtechnology, Milk, Miniaturization, Mobile Applications, Models, Molecular, Molecular Biology, Molecular Diagnostic Techniques, Molecular Dynamics Simulation, Molecular Probes, Molecular Sequence Annotation, Molecular Sequence Data, Molecular Targeted Therapy, Molecular Typing, Monitoring, Mouth, Mouth Diseases, Mouth Neoplasms, Multigene Family, Multiple, Multiple Sclerosis, Muscle, Mutagenesis, Mutation, NF-kappa B, Nanoparticles, Nanostructures, Nanotechnology, Needs Assessment, Neonatal, Neoplasms, Neoplastic Stem Cells, Neurodegenerative Diseases, Neurodevelopmental Disorders, Neuroimmunomodulation, Neuropsychiatry, Neurosecretory Systems, Newborn, Nitric Oxide, Non-Small-Cell Lung, Non-Steroidal, Non-alcoholic Fatty Liver Disease, Nucleic Acid Amplification Techniques, Nucleic Acids, Nucleotide, Nursing Methodology Research, Nutritional Physiological Phenomena, Nutritional Status, Obesity, Oceans and Seas, Ochratoxins, Oligonucleotide Array Sequence Analysis, Oocytes, Optical Imaging, Oral Health, Organ Culture Techniques, Organ Specificity, Organizational, Oropharyngeal Neoplasms, Oxidative Stress, Paper, Parasites, Parasitic Diseases, Parasitology, Particle Size, Parturition, Patient Care Management, Peptides, Peri-Implantitis, Periodontitis, Permeability, Pest Control, Pesticides, Pharmacology, Phase I, Phase II, Phenotype, Photochemical Processes, Phylogeny, Phylogeography, Physiologic, Physiological, Phytoestrogens, Phytotherapy, Pituitary-Adrenal System, Placenta, Planet, Plant Cells, Plant Development, Plant Diseases, Plant Exudates, Plant Roots, Plant Tumors, Plants, Pluripotent Stem Cells, Point-of-Care Systems, Point-of-Care Testing, Polymerase Chain Reaction, Polymers, Polymorphism, Polystyrenes, Population, Population Dynamics, Prebiotics, Precision Medicine, Preclinical, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Premature, Preschool, Prescription Drugs, Printing, Probiotics, Prognosis, Prostate, Prostatic Neoplasms, Proteins, Proteome, Proteomics, Proton-Motive Force, Pseudomonas aeruginosa, Pseudomonas fluorescens, Psoriasis, Psychotropic Drugs, Public Health, Pulmonary Disease, Pyrrolidonecarboxylic Acid, Quality Control, Quantum Dots, RNA, RNA Viruses, Raman, Real-Time Polymerase Chain Reaction, Reflex, Regenerative Medicine, Reproducibility of Results, Reproductive Health, Reproductive Techniques, Reproductive Tract Infections, Reptiles, Research, Research Design, Respiratory System, Respiratory Tract Diseases, Retinal Diseases, Reverse Transcription, Rheumatic Diseases, Rheumatoid, Rhizosphere, Ribosomal, Risk Assessment, Risk Factors, Robotics, Routine, SOS Response, Saccharomyces cerevisiae, Saliva, Scanning, Sea Anemones, Seawater, Sebum, Secondary Metabolism, Seeds, Selection, Sensitivity and Specificity, Sepharose, Sequence Analysis, Sex Factors, Sigma Factor, Signal Transduction, Single Nucleotide, Single-Cell Analysis, Skeletal, Skin, Skin Aging, Skin Diseases, Skin Physiological Phenomena, Smartphone, Smoking, Software, Soil, Soil Microbiology, Sound, Soy Foods, Spatio-Temporal Analysis, Species Specificity, Spectrophotometry, Spectrum Analysis, Sphagnopsida, Spheroids, Spores, Stem Cell Niche, Stem Cells, Stereoisomerism, Stochastic Processes, Stomach Neoplasms, Streptococcal Infections, Streptococcus, Stress, Substance Abuse Detection, Surface Properties, Sweat, Symbiosis, Synbiotics, Synthetic Biology, Systems Biology, Tears, Technology Transfer, Terminology as Topic, Theoretical, Therapeutics, Thermus, Thiazolidines, Three-Dimensional, Tick-Borne Diseases, Ticks, Time, Time Factors, Time-Lapse Imaging, Tissue Array Analysis, Tissue Culture Techniques, Tissue Distribution, Tissue Engineering, Tissue Scaffolds, Toxicology, Transcriptome, Translational Medical Research, Treatment Outcome, Tuberculosis, Tumor, Tumor Microenvironment, Type 1, Type 2, U937 Cells, Urinary Incontinence, Urine, Urogenital System, Urologic Diseases, Uterus, Uveitis, Vagina, Vaginosis, Vagus Nerve, Verrucomicrobia, Vertebrates, Vertical, Veterinary Drugs, Video, Viral Proteins, Virology, Virus Diseases, Viruses, Volatile, Water, Water Microbiology, Water Pollutants, Waterborne Diseases, Wearable Electronic Devices, Weight Gain, Xenobiotics, Yeasts, Zebrafish, administration & dosage, adverse effects, analysis, antagonists & inhibitors, beta-Defensins, biosynthesis, blood, chemical synthesis, chemistry, classification, complications, cytology, diagnosis, diet therapy, drug effects, drug therapy, epidemiology, etiology, genetics, growth & development, immunology, instrumentation, isolation & purification, metabolism, methods, microbiology, mortality, nursing, organization & administration, pathogenicity, pathology, pharmacokinetics, pharmacology, physiology, physiopathology, prevention & control, psychology, standards, statistics & numerical data, therapeutic use, therapy, toxicity, transmission, trends, ultrastructure, veterinary, virology",
author = "{Contributing Authors} and David Berry and Alexander Loy and Bryan Coburn and Guttman, {David S} and Francesca Luca and Kupfer, {Sonia S} and Dan Knights and Alexander Khoruts and Ran Blekhman and Matsen, {Frederick A 4th} and McBain, {Andrew J} and O'Neill, {Catherine A} and Alejandro Amezquita and Price, {Laura J} and Karoline Faust and Adrian Tett and Nicola Segata and Swann, {Jonathan R} and Smith, {Adrian M} and Barry Murphy and Michael Hoptroff and Gordon James and Yugandhar Reddy and Anindya Dasgupta and Tom Ross and Chapple, {Iain L} and Wade, {William G} and Judith Fernandez-Piquer and Fulbright, {Laura E} and Melissa Ellermann and Arthur, {Janelle C} and Foster, {J A} and Andres Gomez and Swanson, {K S} and Williams, {D A} and Michael Silverman and Andres Gomez and Johnson, {Timothy J} and Prince, {Amanda L} and Chu, {Derrick M} and Jun Ma and Lei Wang and Chen Wang and Klatt, {Nichole R} and Williams, {Michael J M} and Qing Li and Kim, {Hyun Jung} and Yan Li and Lei Zhang and Wei Zhang",
year = "2018",
doi = "10.1038/s41477-018-0139-4",
language = "English (US)",
isbn = "1473-0197",
series = "Current opinion in biotechnology",
publisher = "Springer US",
pages = "247--257",
booktitle = "Current opinion in biotechnology",
}
